This Cooperative Agreement award, funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,175,074 to support a research project investigating the role of mid-life environmental toxicant exposures on the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project, led by the University of Pennsylvania, will leverage the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) study to repeatedly measure...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,499,382 in funding to Duke University to advance research on the role of chemical exposures in Alzheimer's disease (AD) and related dementias. The project aims to expand coverage of the chemical exposome in blood and brain, and link identified signatures to brain aging, incident dementia, and AD. Key activities include metabolomics and lipidomics analyses, integrating exposome data...
The National Institute on Aging (NIA) awarded a 5-year, $2,533,483 Cooperative Agreement (CFDA 93.866 - Aging Research) to Columbia University to prospectively examine the relationship between environmental toxicants and the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project will leverage the existing Diabetes Prevention Program Outcomes Study (DPPOS) AD/ADRD cohort to conduct longitudinal untargeted exposomics, metabolomics, and measurements of metals, polyfluoroalkyl...
The National Institute on Aging (NIA) has awarded a $3,925,264 Cooperative Agreement under the Aging Research (CFDA 93.866) Federal Grant Program to the University of New Mexico Health Sciences Center (UNM HSC). The award, titled "PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia", will fund a comprehensive preclinical program to investigate the impacts of environmental stressors such as wildfire smoke, microplastics, and heavy metals on the...
This $767,193 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) supports research to identify undiagnosed Alzheimer's disease (AD) in underserved Hispanic/Latino and African American populations. The key products and services to be delivered under this award include: Identifying disease trajectories associated with AD to help predict undiagnosed cases, while accounting for underdiagnosis bias in the target populations (Aims 1-2). Integrating...
This $3,915,141 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support research at Emory University to investigate the relationship between air pollution exposure, specifically fine particulate matter (PM2.5), and Alzheimer's disease and related dementias (AD/ADRD). The key objectives are to determine 1) which specific PM2.5 components are most neurotoxic, 2) the role of other common air pollutants like carbon monoxide and ozone, and 3) the...
This Cooperative Agreement award of $763,225 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify gene-environment interactions (GxE) that contribute to the risk of Alzheimer's disease (AD). The project will use an in vitro "GxE in a dish" model with 100 induced pluripotent stem cell (iPSC) donors to assess the context-specific function of common genetic variants. Researchers will expose cortical organoids derived from these iPSCs to...
This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) totaling $424,184 aims to understand racial and ethnic disparities in access to Alzheimer's Special Care Units (SCUs) in nursing homes and how this access affects health outcomes. The project will: 1) Examine disparities in SCU access among Black and Hispanic residents with Alzheimer's disease and related dementias (ADRD); 2) Assess how SCU access contributes to disparities in ADRD...
This federal Project Grant award for $372,690, provided by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program, is focused on discovering the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The primary goals are to: (1) develop new statistical methods for uncovering heterogeneous causal relationships between amyloid-beta, tau accumulation, and cognition across diverse AD patient subpopulations; (2) apply these novel methods to existing AD...
The National Institute on Aging (NIA) awarded a 5-year, $2,278,304 Cooperative Agreement (CFDA 93.866 - Aging Research) to Emory University to investigate the biological mechanisms by which exposures to fine particulate matter (PM2.5) air pollution contribute to the development of Alzheimer's disease and related dementias (ADRD). The project, titled "IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and Their Contribution to Alzheimer's...