Effects of leptin modulation on health span and lifespan
Active Project Grant Awarded Last action
- Award ID
- R01AG084646
- Recipient
-
The University Of Texas Health Science Center At San Antonio UEI C3KXNLTAAY98
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,627,378
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 44% complete
- Place of performance
- San Antonio, TX 78229, USA
Award details come from USAspending.gov.
Description
- Abstract
- The overall objective of the research proposal is to explore the impact of leptin modulation on healthspan and lifespan. Aging is associated with a dramatic increase in visceral adiposity that contributes to elevated circulating leptin and leptin resistance. Our recent publications in science translational medicine, diabetes, cell metabolism and molecular metabolism have clearly indicated hyperleptinemia is a driving force for diet or antipsychotic drug-induced obesity and its associated metabolic disorders, and partial leptin reduction protects the mice from obesity and tissue dysfunction. Furthermore, our preliminary results suggest that chronic hyperleptinemia drives cellular senescence in cultured preadipocytes, proving a potential mechanism for increased inflammation and reduced capacity to differentiate into mature adipocytes. In addition, reducing circulating leptin, achieved by a genetic approach, significantly extend both median and maximum lifespan. Based on these observations, we proposed our central hypothesis that leptin modulation is a new means to regulate both healthspan and lifespan via leptin-driven cellular senescence. With our newly generated mouse models and customized leptin neutralizing antibody, along with numerous resources at SAN antonio nathan shock center, we will assess the effect of leptin modulation in healthspan and lifespan with three specific aims. Aim 1 is to test whether aging-associated hyperleptinemia accelerates cellular senescence and impairs healthspan and lifespan; aim 2 is to access the effects of reducing leptin on cellular senescence, healthspan, and lifespan; aim 3 will elucidate the underlying mechanism(S) mediating leptin-driven cellular senescence. All three specific aims work together to establish a novel mechanism for metabolic aging and set the stage for trials of leptin-based therapeutics in humans to reduce age-related diseases and extend healthspan and lifespan.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $647,245 | |
| Amendment | $640,217 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $669,958 | |
| Original award | $669,958 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Cedars-Sinai Medical Center | $57,542 | |
| University Of North Dakota | $56,963 |
Quick answers
Who received award R01AG084646?
R01AG084646 was awarded to The University Of Texas Health Science Center At San Antonio by National Institute on Aging (National Institutes of Health) on September 22, 2024.
How much is award R01AG084646 worth?
$2,627,378 has been obligated on R01AG084646.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award