Examining the persistence of neurocognitive benefits of exercise

Ended Project Grant Awarded Last action

Award ID
R01AG083156
Recipient
Awarding agency
Obligated
$11,485,569

Award facts

Assistance listing
93.866 Aging Research
Completion date
Place of performance
Orlando, FL 32803, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Physical activity (PA) is one of the most promising approaches for mitigating age-related cognitive decline and risk for dementia, yet few sufficiently powered randomized clinical trials (RCT) targeting brain health outcomes have been conducted. Further, little is known about the biological pathways and moderators of the brain response to exercise. To address these gaps, we have conducted a multi-site, supervised, dose-response (150MIN/WK of moderate-intensity; 225MIN/WK of moderate-intensity; 150MIN/WK of light intensity), aerobic exercise RCT with brain health outcomes as the primary endpoints in 648 cognitively normal adults between 65-80 years of age. This study, investigating gains in neurocognition in an intervention trial of exercise (IGNITE), was funded by the NIH in 2016. The RCT has been enormously successful in terms of exceeding sample size expectations, maintaining high adherence and compliance (>80%), minimal missing data, improving cardiorespiratory fitness, and achieving the expected distribution of under-represented minorities (25% non-white). The results from IGNITE are bound to be transformative, but there will remain many unanswered questions after the conclusion of IGNITE that we intend to address in this proposal. For example, does a 12-month aerobic exercise RCT have any persistent or protracted benefits to cognitive, neural, or neuropathological outcomes 5-years after the completion of the intervention? Was the RCT effective at modifying long-term exercise behaviors? Can we utilize the rich participant data of IGNITE to forecast who is more likely to maintain a physically active lifestyle after the completion of the intervention? How effective was the exercise RCT for modifying the accumulation of alzheimer's disease (ad) neuropathology over a 5-year follow-up? And, finally, if cognitive, brain, or markers of neuropathology are different as a function of group assignment 5-years after the completion of the intervention, which factors mediate those long-term benefits? The answers to these questions will have significant scientific and public health implications that we will address in a cost-effective manner by conducting a 5-year follow-up evaluation of IGNITE participants. We focus on 4 key aims and one discovery science aim: aim 1: test the effects of the IGNITE exercise RCT on cognitive performance 5-years after the completion of the intervention. Aim 2: examine the extent to which participants maintained exercise behaviors 5-years after the completion of the intervention. Aim 3: test whether the intervention modified 5-year accumulation of ad neuropathology. Aim 4: test whether the exercise RCT influenced 5-year follow-up of neuroimaging markers of brain health. Discovery science aim: explore whether participant characteristics at baseline predict long-term engagement in exercise behaviors after the completion of the intervention.

Transactions

Action Obligated Date
Amendment $0
Amendment $2,284,063
Amendment $2,112,851
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $0
Amendment $2,362,885
Amendment $2,362,885
Original award $2,362,885
Show all 11

Subawards

Subrecipient Amount Awarded
Northeastern University Northeastern University is one of the three recruitment sites for this project, which will recruit participants from the NIH-funded multi-site randomized… $469,218
University Of Kansas Medical Center Research Institute, Inc. The University of Kansas Medical Center (KUMC) will serve as a site for this new project to extend assessment of prior participants in the “Investigating… $50,204
University Of Kansas Medical Center Research Institute, Inc. The University of Kansas Medical Center (KUMC) will serve as a site for this new application to extend assessment of prior participants in the “Investigating… $400,405
University Of Pittsburgh - Of The Commonwealth System Of Higher Education PROJECT GOALS Aim 1: Test the effects of the IGNITE exercise RCT on cognitive performance 5-years after the completion of the intervention. Aim 2: Examine the… $674,693
Northeastern University Northeastern University is one of the three recruitment sites for this project, which will recruit participants from the NIH-funded multi-site randomized… $450,519
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The University of Pittsburgh (Pitt) will act both as a data collection site for prior participants in the IGNITE study as well as acting as the primary… $685,633
Northeastern University Northeastern University is one of the three recruitment sites proposed in the current R01 application, which has the aim of recruiting participants from the… $459,848
University Of Kansas Medical Center Research Institute, Inc. The University of Kansas Medical Center (KUMC) will serve as a site for this new application to extend assessment of prior participants in the… $399,284
Northeastern University Northeastern University is one of the three recruitment sites proposed in the current R01 application, which has the aim of recruiting participants from the… $1,376,620
University Of Kansas Medical Center Research Institute, Inc. The University of Kansas Medical Center (KUMC) will serve as a site for this new application to extend assessment of prior participants in the… $1,257,464
University Of Pittsburgh - Of The Commonwealth System Of Higher Education The University of Pittsburgh (Pitt) will act both as a data collection site for prior participants in the IGNITE study as well as acting as the primary… $2,132,675
Show all 11

Quick answers

Who received award R01AG083156?

R01AG083156 was awarded to Adventist Health System / Sunbelt Inc. by National Institute on Aging (National Institutes of Health) on September 1, 2023.

How much is award R01AG083156 worth?

$11,485,569 has been obligated on R01AG083156.

On GovTribe

See this award's full record

  • Every transaction and subaward
  • The recipient's other awards and teaming partners
  • Similar grant awards
  • Ask GovTribe AI about this award
Try for free Login