Project Grant R01AG080398
- This federal Project Grant award of $641,516 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will support research to examine the longitudinal relationship between psychological risk factors (stress, depression, substance use) and cognitive performance among American Indian (AI) adults. The research, conducted by the Huntington Medical Research Institutes (HMRI), aims to evaluate whether health-related quality of life and community connectedness moderate...
- The National Institute on Aging (NIA) awarded a $519,740 Project Grant to Washington State University to conduct the "Communicating Heath Advancements from Native Genetics Research (CHANGE Research)" project under the Aging Research federal grant program (CFDA 93.866). The project aims to partner with the United Indians of All Tribes Foundation to survey 500 American Indian and Alaska Native (AI/AN) adults about their knowledge and perceptions of Alzheimer's disease and related...
- This $4,444,978 federal Project Grant award, issued by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research to characterize cognitive reserve and identify modifiable factors that promote cognitive reserve and resilience to Alzheimer's disease and related dementias (ADRD) among older adults in India, with a focus on those who lack formal education. The project aims to: 1) compare brain pathology measures and their contributions to cognition between older...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $460,844 to The Trustees of Columbia University in the City of New York to conduct the "LIFE-COURSE ACCULTURATION TRAJECTORIES AND DEMENTIA IN A MULTI-ETHNIC COHORT OF OLDER ADULTS: THE MESA ACCULTURATION AND DEMENTIA STUDY". The study aims to leverage longitudinal data from the Multi-Ethnic Study of Atherosclerosis (MESA) to identify unique life-course acculturation patterns among...
- This Project Grant award of $353,391.00, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to validate the use of a "Personal Learning Curve" paradigm as a sensitive marker of early memory decline related to Alzheimer's disease (AD) biomarkers in a large, diverse sample of older adults. The study seeks to determine if this digital cognitive assessment tool, which measures learning over repeated evaluations, can detect subtle AD-related memory failures...
- The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $287,386 project grant to the American Samoa Community Cancer Coalition (ASCCC) to conduct a culturally grounded assessment of Alzheimer's disease and related dementia (ADRD) knowledge, attitudes, and behaviors among American Samoan family caregivers. This 2-year project, beginning May 1, 2025, aims to: 1) determine caregivers' ADRD knowledge, attitudes, and behaviors using...
- The Cooperative Agreement award of $200,000 from the Indian Health Service (IHS) Health Management Development Program (CFDA 93.228) will support the Dementia Screening Project (DSP) conducted by First Nations Community Health Source Inc. (FNCH), a non-profit urban Indian health center in Albuquerque, New Mexico. The project aims to implement an evidence-based, culturally sensitive, and integrated dementia screening and education program targeting 100 American Indian and Alaska Native (AI/AN)...
- This Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support a longitudinal investigation of the relationship between bilingualism, executive function, and brain organization in individuals with Autism Spectrum Disorder (ASD). The $691,353 award, beginning April 1, 2025 and running through December 31, 2029, will enable researchers at the University...
- This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the CFDA program "Child Health and Human Development Extramural Research" (93.865) will provide $431,750.00 to the University of California, Los Angeles (UCLA) to conduct an exploratory investigation on bilingualism, executive function, and brain organization in children with Autism Spectrum Disorder (ASD). The project aims to 1) characterize the associations between bilingualism...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $420,947 to the Regents of the University of Michigan to conduct preliminary work for developing a nationally representative, longitudinal, population-based study in Guatemala to assess aging outcomes, including Alzheimer's disease and related dementias. The project has three key aims: 1) Select and translate key survey modules, including cognition and dementia assessments, from Spanish to Mayan...
BILINGUALISM AS A PROTECTIVE FACTOR OF ADRD IN AMERICAN INDIAN ADULTS: THE STRONG HEART STUDY - PROJECT SUMMARY/ABSTRACT AMERICAN INDIAN POPULATIONS HAVE GREATER BURDEN OF CEREBROVASCULAR AND ALZHEIMER'S DISEASE AND RELATED DEMENTIAS (ADRD) COMORBIDITIES COMPARED WITH NON-HISPANIC WHITE U.S. POPULATIONS AND MAY ALSO HAVE GREATER BURDEN OF COGNITIVE DECLINE AND DEMENTIA. BILINGUALISM-COMMON IN AMERICAN INDIAN COMMUNITIES- MAY ENHANCE WORKING MEMORY CAPACITY, ATTENTIONAL CONTROL, AND COGNITIVE RESERVE, THUS REDUCING COGNITIVE RISK. HOWEVER, BILINGUALISM IS A HIGHLY INDIVIDUAL EXPERIENCE, AND THE CONTEXT OF USE CAN MODIFY ITS COGNITIVE EFFECTS. FACTORS THAT MAY INFLUENCE THIS ASSOCIATION INCLUDE AGE, SEX, VOCABULARY, PHYSICAL AND MENTAL STATUS, SOCIOECONOMIC STATUS, CULTURE, AND SOCIAL ACTIVITY. COMPREHENSIVELY ASSESSING THE RELATIONSHIP BETWEEN BILINGUALISM AND COGNITIVE PERFORMANCE MAY BE CRITICAL TO FULLY UNDERSTANDING ADRD IN AMERICAN INDIAN ADULTS. ALTHOUGH THE LINK BETWEEN BILINGUALISM AND COGNITIVE RESERVE HAS BEEN STUDIED IN MANY POPULATIONS, BILINGUALISM RESEARCH IN AMERICAN INDIAN POPULATIONS HAS BEEN LIMITED, DUE IN PART TO CRITICAL COFACTORS RELATED TO THEIR EXPERIENCES, PERSPECTIVES, AND STANDARDIZED ASSESSMENTS. UNJUST UNITED STATES (U.S.) FEDERAL POLICIES AFFECTING AMERICAN INDIAN PEOPLE INCLUDED FORCED ATTENDANCE AT ENGLISH-SPEAKING BOARDING SCHOOLS WHERE USE OF NATIVE LANGUAGES WAS PUNISHED, AND CULTURAL ASSIMILATION WAS PRIORITIZED OVER QUALITY OF EDUCATION. AS A RESULT, BILINGUALISM IN AMERICAN INDIAN ADULTS WHO ATTENDED SUCH SCHOOLS MAY PRESENT DIFFERENTLY THAN FOR OTHER POPULATIONS. INDEED, NIA (RFA-AG-23-001) DEFINES BILINGUALISM AS "PROFICIENCY IN TWO OR MORE LANGUAGES", HOWEVER NO VALIDATED, DETAILED ASSESSMENT OF PROFICIENCY EXISTS FOR U.S. NATIVE LANGUAGES, OR FOR AMERICAN INDIAN SPEAKERS OF THOSE LANGUAGES. OUR PROPOSED STUDY WILL BE THE FIRST TO CULTURALLY ADAPT A LANGUAGE USE AND HISTORY INSTRUMENT IN A LARGE, HETEROGENEOUS AMERICAN INDIAN POPULATION. IN RESPONSE TO RFA-AG-23-001, WE WILL LEVERAGE THE STRONG HEART STUDY, A LARGE, LONGITUDINAL, HETEROGENEOUS, POPULATION-BASED STUDY OF AGING IN AMERICAN INDIAN ADULTS OVER 3 GEOGRAPHIC REGIONS (N=2,500). IN THIS PROPOSED WORK, WE WILL BUILD ON THIS STUDY, AS WELL AS OUR PRIOR WORK, TO ASSESS THE CONTINUUM OF BILINGUALISM IN AMERICAN INDIAN PEOPLES BY CULTURALLY ADAPTING THE LANGUAGE HISTORY QUESTIONNAIRE, EVALUATE BILINGUALISM IN AMERICAN INDIANS OF MULTIPLE GENERATIONS IN ASSOCIATION WITH A DETAILED COGNITIVE PERFORMANCE BATTERY, AND CONSTRUCT CONCEPTUAL MODELS TO ASSESS INTERVARIABLE RELATIONSHIPS INCLUDING EFFECT MODIFICATION AND MODERATION BY CRYSTALLIZED COGNITION. THIS PROJECT WILL ILLUMINATE QUESTIONS OF PUBLIC HEALTH SIGNIFICANCE IN A VULNERABLE POPULATION THAT REMAINS UNDERREPRESENTED IN ADRD RESEARCH, WITH POTENTIAL IMPLICATIONS FOR FUTURE PREVENTION AND TREATMENT STRATEGIES.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $56.1k | 7/16/25 | ||
| Not listed | $56.1k | 7/16/25 | ||
| Not listed | $56.1k | 7/16/25 | ||
| Not listed | $0 | 6/18/25 | ||
| Not listed | $0 | 6/18/25 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
142423WSU001049AS | Medstar Health Research Institute Inc. | Project Grant R01AG080398 | $166.9k | 2/23/24 | |
142423WSU001076AS | University Of Oklahoma | Project Grant R01AG080398 | $104.0k | 2/20/24 | |
142423WSU001220AS | Huntington Medical Research Institutes | Project Grant R01AG080398 | $75.2k | 2/12/24 | |
142423WSU001074AS | Missouri Breaks Industries Research, Inc. | Project Grant R01AG080398 | $99.7k | 2/2/24 | |
142423WSU001074S | Missouri Breaks Industries Research, Inc. | Project Grant R01AG080398 | $92.7k | 9/19/23 |