SEX-specific genetic drivers of alzheimer's disease endophenotypes
Ended Project Grant Awarded Last action
- Award ID
- R01AG073439
- Recipient
-
Vanderbilt University Medical Center UEI GYLUH9UXHDX5
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $4,867,911
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date
- Place of performance
- Forest Hills, TN 37215, USA
Award details come from USAspending.gov.
Description
- Abstract
- As the population ages, late-onset alzheimer's disease (ad) is becoming an increasingly important public health issue. Ad disproportionately affects women. Of the more than 5 million people in the united states afflicted with this disease, two-thirds are women. Women with ad have more neuropathology than men with ad, have more severe cognitive symptoms, and more severe neurodegeneration, suggesting that the disease affects male and female brains in different ways. Thus, a focus on SEX differences in ad is essential to move the field towards effective interventions. The identification of SEX-specific genetic drivers of ad and ad-related endophenotypes could transform the way treatments are administered and be a critical step towards personalized interventions for ad. Research from both our group and others has begun to uncover genetic factors that explain some of the observed differences between males and females, specifically in terms of ad neuropathology and cognitive decline. To advance the field, additional genetic effects must be discovered and the underlying mechanisms of SEX-specific pathways of injury must be examined. The objective of this project is to identify and replicate genetic effects that act in a SEX-specific manner to drive the neuropathological presentation and clinical progression of ad. The present proposal will advance our understanding of SEX- specific genetic contributors to ad endophenotypes by leveraging data from 30 studies of aging and ad (N=33,740) to assess genetic associations with ad neuropathology and cognitive decline. The outcome of this project will highlight new candidate pathways and begin the process of characterizing the mechanisms by which genetic variation among males and females affects the risk and clinical symptoms of ad. The SEX- specific pathways identified will offer therapeutic targets and help move the field towards personalized interventions that consider an individual's SEX and neuropathological presentation.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $745,408 | |
| Amendment | $780,953 | |
| Amendment | $800,024 | |
| Amendment | $800,024 | |
| Amendment | $830,859 | |
| Amendment | $0 | |
| Original award | $910,643 |
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| The Washington University | $160,726 | |
| University Of Washington | $33,344 | |
| Rush University Medical Center | $42,745 | |
| The General Hospital Corporation | $40,533 | |
| University Of Wisconsin System | $14,918 | |
| The Washington University | $167,753 | |
| University Of Washington | $37,975 | |
| Rush University Medical Center | $48,445 | |
| University Of Wisconsin System | $16,906 | |
| The Washington University | $201,304 | |
| The General Hospital Corporation | $45,928 |
Show all 11
Quick answers
Who received award R01AG073439?
R01AG073439 was awarded to Vanderbilt University Medical Center by National Institute on Aging (National Institutes of Health) on September 13, 2021.
How much is award R01AG073439 worth?
$4,867,911 has been obligated on R01AG073439.
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