Longitudinal study of HIV and aging in brazil
Active Project Grant Awarded Last action
- Award ID
- R01AG071439
- Recipient
-
Vanderbilt University Medical Center UEI GYLUH9UXHDX5
- Awarding agency
-
National Institute on Aging
National Institutes of Health, Department of Health and Human Services
- Obligated
- $11,013,145
Award facts
- Assistance listing
- 93.866 Aging Research
- Completion date 91% complete
- Originally
- Funding
-
- $10,330,292.00 Federal
- $682,853.00 Non-federal
- Place of performance
- Nashville, TN 37203, USA
Award details come from USAspending.gov.
Description
- Abstract
- This study will investigate the epidemiology, clinical implications, and immunologic and infectious determinants of aging-related diseases and outcomes in older people with HIV (PWH) in brazil. In part a result of the long- term effects of HIV infection and ongoing inflammation, older PWH experience high rates of non-communicable diseases (ncds) and early onset of geriatric syndromes including frailty, disability, and cognitive decline. However, HIV is not alone as a chronic infection that can cause inflammation and other immunological changes associated with these outcomes. Our knowledge of how other chronic infections endemic to low-and middle-income countries affect the pathogenesis and epidemiology of geriatric syndromes in is lacking. A middle-income country with a large population of older PWH, brazil has a history of comprehensive HIV care as well as endemic chronic infections. This diverse, longitudinal study will recruit PWH on antiretroviral therapy =50 years of age in three brazilian cities (n=360 ages 50-64YEARS and n=340 ages =65 years) to evaluate the ways coinfections such as TB, htlv-1, chagas disease, toxoplasmosis, and others affect the epidemiology and immunologic pathways of aging-related morbidity. We will examine the association of syndemics of coinfections and social determinants of health with validated ncds. We will prospectively evaluate how individual and cumulative burden of coinfections predict incident geriatric syndromes. We will evaluate a novel screening tool to assess vulnerability of older PWH for adverse clinical outcomes including death, hospitalization, and new disability. This study will also investigate how coinfections affect biologic pathways of inflammation which contribute to development of ndcs and geriatric syndromes building upon established and productive collaborations in HIV observational research in latin america, this study is uniquely positioned to provide urgently needed, high-quality data to understand aging with HIV in a global context. IT will offer novel insights into a diversity of infectious contributions to cellular mechanisms of aging experienced by PWH around the globe.
Transactions
| Action | Federal | Non-federal | Date |
|---|---|---|---|
| Amendment | $0 | $0 | |
| Amendment | $51,880 | $0 | |
| Amendment | $51,880 | $0 | |
| Amendment | $583,669 | $0 | |
| Amendment | $583,669 | $0 | |
| Amendment | $654,308 | $0 | |
| Amendment | $654,308 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $435,598 | $0 | |
| Amendment | $435,598 | $0 | |
| Amendment | $694,692 | $0 | |
| Amendment | $694,692 | $0 | |
| Amendment | $694,692 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $0 | $0 | |
| Amendment | $371,202 | $0 | |
| Amendment | $371,202 | $0 | |
| Amendment | $371,202 | $0 | |
| Amendment | $371,202 | $0 | |
| Amendment | $648,264 | $0 | |
| Amendment | $648,264 | $0 | |
| Amendment | $648,264 | $0 | |
| Amendment | $682,853 | $0 | |
| Original award | $682,853 | $682,853 |
Show all 30
Subawards
Show all 17
Quick answers
Who received award R01AG071439?
R01AG071439 was awarded to Vanderbilt University Medical Center by National Institute on Aging (National Institutes of Health) on August 15, 2021.
How much is award R01AG071439 worth?
$11,013,145 has been obligated on R01AG071439: $10,330,292 in federal funding and $682,853 in non-federal funding.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award