Project Grant R01AG070822

This $200,310 project grant from the Department of Health and Human Services' National Institutes of Health National Institute on Aging will fund research into the differential impact of adverse childhood experiences and aging on brain health. Specifically, the Oklahoma State University grant will pursue two aims: 1) characterize cognitive performance across emerging and older adult cohorts stratified by ACEs, and 2) characterize brain-derived neurotrophic factor levels across the two age...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $460,844 to The Trustees of Columbia University in the City of New York to conduct the "LIFE-COURSE ACCULTURATION TRAJECTORIES AND DEMENTIA IN A MULTI-ETHNIC COHORT OF OLDER ADULTS: THE MESA ACCULTURATION AND DEMENTIA STUDY". The study aims to leverage longitudinal data from the Multi-Ethnic Study of Atherosclerosis (MESA) to identify unique life-course acculturation patterns among...

This $562,314 federal Project Grant awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866) supports a 3-year study to identify risk and protective factors associated with psychosocial resilience in spousal caregivers for spouses with Alzheimer's disease and related dementias. The study leverages data from several large, longitudinal cohort studies, including the Health and Retirement Study, to examine how caregivers' well-being, mental health, and cognitive...

The National Institute on Aging (NIA) awarded a $331,270 Project Grant (CFDA 93.866 - Aging Research) to the University of Houston System to study the association between place, stress, and cognitive status among middle-aged and older Black men. The 2-year project aims to leverage data from the Health and Retirement Study and U.S. Census to introduce and evaluate a conceptual model examining how residential environments may impact the relationship between stress and cognitive impairment in...

This $2,366,213 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund the INLIFE (Individualized Lifestyle Change for Every Aging Brain) study. The study aims to harmonize and analyze participant-level data from 12 U.S. randomized controlled trials to examine how changes in lifestyle behaviors such as physical activity, cognitive activity, diet, and social engagement impact cognitive outcomes across diverse older adult populations....

This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $2,300,176 to Florida State University (FSU) to investigate how the personality trait of interpersonal conscientiousness supports cognitive health and lowers the risk of dementia. The research aims to identify the clinical, behavioral, psychological, and relational mechanisms by which interpersonal conscientiousness protects cognition, both in laboratory assessments and in...

Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...

Grant Award Summary The National Institute on Aging (NIA) awarded a $3.52 million Project Grant to the University of California, Davis, effective March 15, 2026, through November 30, 2030, under the Aging Research program (CFDA 93.866). This continuation award, titled "Longitudinal MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of Latinos (SOL-INCA-MRI Long)," delivers longitudinal neuroimaging research services and biomarker analysis to advance understanding of...

This Project Grant award of $353,391.00, provided by the National Institute on Aging (CFDA 93.866 - Aging Research), aims to validate the use of a "Personal Learning Curve" paradigm as a sensitive marker of early memory decline related to Alzheimer's disease (AD) biomarkers in a large, diverse sample of older adults. The study seeks to determine if this digital cognitive assessment tool, which measures learning over repeated evaluations, can detect subtle AD-related memory failures...

Project Grant Award Summary The National Institute on Aging awarded University of California, Davis a $3.42 million Project Grant (CFDA 93.866, Aging Research) on September 15, 2025, to develop and validate digital biomarkers capturing the dynamic relationship between social and cognitive health as early indicators of Alzheimer's disease and related dementias (AD/ADRD). Over the four-year project period through September 2029, the research team will address three critical gaps in understanding...