Project Grant R01AG054324

This Project Grant award of $616,200 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research at Georgetown University to study the role of granzymes, a family of immune system proteins, in promoting vascular inflammation and injury in people living with HIV. The key objectives are to: 1) Characterize the regulation of granzyme expression in different subsets of memory CD8 T cells and virus-specific CD8 T cells...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), is focused on understanding the mechanisms underlying HIV-associated hypertension and cardiovascular disease. The $641,960 award, granted to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), will fund research to investigate how HIV-derived proteins, specifically the Tat protein, contribute to the development of...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), is focused on mentoring early-career researchers in sex and gender-informed multidisciplinary research on cardiometabolic comorbidities in persons living with HIV (PWH). The $123,104 award to Emory University, which began on January 1, 2025, will support two research aims: 1) assessing relationships between the metabolome, lipidome, HIV reservoir,...

This federal Project Grant award of $771,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research to examine the effects of HIV-associated extracellular vesicles (EVs) containing the protein NEF on macrophage heterogeneity and function, and their contribution to the formation of high-risk atherosclerotic plaques in people living with HIV. The research aims to identify novel mechanisms and therapeutic targets related to impaired...

The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $408,200 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of California, Irvine (UCI). The goal of this 2-year research project, with an award period from Aug 1, 2024 to Jun 30, 2026, is to determine whether nucleic acid-containing immune complexes (ICs) drive the immune activation and endothelial dysfunction that contribute to reduced life expectancy in people...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $635,950 to Duke University to conduct research focused on harnessing CD89+ natural killer (NK) cells for potential therapeutic interventions against HIV and SIV infections. The key objectives are to: (1) characterize the role and functional regulation of CD89+ NK cells in the mucosal tissues of normal and...

This $1,010,290 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at Emory University to investigate the role of alveolar macrophages as potential HIV reservoirs and drivers of residual inflammation and immune activation in people living with HIV (PLWH) on antiretroviral therapy. The study aims to: 1) Determine the contribution of alveolar macrophages as reservoirs...

This Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), is focused on investigating the role of RNA modifications in driving chronic inflammation in people living with HIV (PLWH) who are on antiretroviral therapy (ART). The primary awardee, Trustees of Boston University, will receive $854,360 over the 5-year award period to identify the molecular mechanisms linking specific RNA...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $238,620.00 to Albany Medical College to study the role of protein kinase C epsilon (PKCε) in regulating inflammation and resolution processes in atherosclerosis. The award period runs from Mar 1, 2025 to Feb 28, 2027. The research aims to investigate how PKCε signaling in myeloid cells, such as macrophages, impacts the balance between...

This Project Grant award of $210,600 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the role of "public" immunoglobulin A (IgA) antibodies in regulating the gut microbiome and inflammation in persons living with HIV-1 (PWH). The key objectives are to: Prepare recombinant "public" IgA clonotypes found in HIV-1-uninfected individuals and PWH, and examine...