Project Grant R01AA032511
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of California, San Diego $190,000 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the therapeutic potential of cannabidiol (CBD) in treating alcohol dependence by examining cellular and molecular mechanisms of CBD's effects on neuroadaptations in the basolateral amygdala. The research comprises two specific aims. Aim 1 determines the impact of chronic CBD treatment on GABAergic...
- The National Institute on Alcohol Abuse and Alcoholism awarded Children's Research Institute $648,180 on June 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate mechanisms and potential pharmacotherapy of neurocognitive deficits in fetal alcohol spectrum disorders. The research examines the long-term neurobehavioral impact of prenatal alcohol exposure, with focus on apolipoprotein E (APOE) signaling in the motor cortex as a therapeutic target. The project builds on...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of New Mexico Health Sciences Center $160,744 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate electrophysiological mechanisms of prenatal alcohol exposure (PAE) effects on cognitive control. The project combines translational touchscreen testing and in vivo electrophysiology to determine how PAE impairs executive function domains in mouse models. The research hypothesizes that...
- The National Institute on Drug Abuse awarded $1.343 million to the Trustees of Indiana University on August 1, 2026, for a prospective study of alcohol and cannabis use across perinatal transitions under the Drug Use and Addiction Research Programs (CFDA 93.279). The study examines longitudinal and proximal antecedents of prenatal cannabis use and postpartum alcohol use among women who are heavy drinkers, with particular attention to behavioral factors such as motives and intentions. The...
- The National Institute on Alcohol Abuse and Alcoholism awarded San Diego State University Foundation $435,083 on July 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to develop and validate BRAIN-ONLINE EN ESPAÑOL, a web-based screening tool for fetal alcohol spectrum disorders (FASD). The project addresses diagnostic barriers in FASD detection by testing the Spanish-language version of BRAIN-ONLINE in youth at risk for FASD and typically developing comparison children....
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $1,771,875 under the Alcohol Research Programs (CFDA 93.273) on August 4, 2026, for research into the novel mechanism of nuclear histone deacetylase 4 (HDAC4) in early-life stress-induced alcohol consumption, preference, and tolerance in offspring. The research develops a mouse model using offspring born to dams that experienced prenatal restraint stress during pregnancy to investigate how early-life...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Regents of the University of California, San Francisco $613,750 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate brain glucose metabolism dysfunction in alcohol use disorder. The research examines how alcohol activates the mTORC1 signaling pathway in dopamine D1 receptor-expressing neurons within the nucleus accumbens, leading to suppression of glycolytic enzymes including aldolase A and...
- The National Institute on Alcohol Abuse and Alcoholism awarded Northwestern University $100,228 on December 18, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate projection-specific endocannabinoid signaling mechanisms in ethanol-related behaviors. The research examines how ethanol affects endocannabinoid-cannabinoid receptor type 1 signaling at dorsolateral striatum terminals in the external segment of the globus pallidus, and how altered signaling at these terminals...
- The National Institute on Drug Abuse awarded the University of Washington $699,748 on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct longitudinal neuroimaging and neurobehavioral assessment of infants prenatally exposed to cannabis. The research characterizes neurodevelopmental trajectories and brain changes associated with prenatal cannabis exposure during the critical first 18 months of life, when rapid synaptogenesis, axonal growth, and...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $474,223 on May 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to elucidate brain region- and cell-specific mechanisms of alcohol-induced developmental neurotoxicity and develop precision interventions targeting neuroprotection. The research addresses fetal alcohol spectrum disorder (FASD), which contributes significantly to intellectual disabilities with a prevalence rate of 1-5% in the...
The National Institute on Alcohol Abuse and Alcoholism awarded San Diego State University Foundation $483,653 on September 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the effects of prenatal alcohol and cannabis exposure on vulnerability to later drug use disorders. The project uses a rodent model of prenatal alcohol, THC, or combined exposure via vapor inhalation to identify whether prenatal exposure causes long-lasting alterations in anxiety-like behaviors, motivation to seek and consume alcohol later in life, central nucleus of the amygdala (CEA) neurotransmission, and CEA endocannabinoid signaling in an age- and sex-specific manner. The research addresses the gap in understanding consequences of prenatal cannabis alone or in combination with alcohol, particularly given rising cannabis accessibility and the misconception among pregnant women that cannabis poses no fetal threat. The endocannabinoid system, which both THC and alcohol may disrupt, serves as a common target implicated in brain development and modulation of synaptic transmission in brain regions involved in addiction and anxiety-related disorders. Performance occurs in San Diego, California, with a period of performance extending from September 1, 2026, through June 30, 2031. This is a Project Grant, the standard assistance type for NIH research awards.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/28/26 | ||
| Not listed | $483.7k | 8/20/26 |