Project Grant R01AA031640

Award Date 9/25/24
Completion Date 5/31/29
Dollars Obligated $698K
Federal Grant Program
93.273
Assistance Type
Project Grant
Place of Performance
Providence, RI 02912, USA
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The key objectives are to: 1) characterize alcohol-associated gut dysbiosis using whole genome sequencing of fecal samples; 2) examine how gut microbiome changes at the species/strain level relate to markers of microbial translocation, inflammation, and harmful metabolites; and 3) assess the association between gut bacteria and subclinical CVD markers, CVD risk, and mortality risk. The project leverages data and samples from three existing NIAAA-funded cohort studies involving 583 people with HIV who consume alcohol. A sub-award of unspecified funding to Vanderbilt University Medical Center will support the construction of an analytic dataset combining data from the three studies with the new fecal microbiome data.

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