Ethanol modulation of a NE-astrocyte-DA arousal pathway

Active Project Grant Awarded Last action

Award ID
R01AA031269
Recipient
Awarding agency
Obligated
$1,543,238

Award facts

Assistance listing
93.273 Alcohol Research Programs
Completion date 48% complete
Place of performance
Worcester, MA 01655, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Alcohol use disorder (AUD) is a highly prevalent public health problem for which there are few effective treatments. Sleep disturbances are highly comorbid with AUD and contribute significantly to disorder progression. Moreover, sleep disturbances can be more difficult to treat in individuals with AUD. Thus a critical need is to understand the mechanisms by which alcohol regulates sleep behavior. Alcohol is well known to reduce sleep latency, however this is followed by increased sleep fragmentation and problems with insomnia in individuals with AUD. Alcohol is well known to have sedative properties, and subsequent insomnia-related AUD symptoms have been proposed to be due to tolerance related disruptions in sleep-related setpoints. Recently, we uncovered a novel pathway by which norepinephrine engages wake- active dopamine neurons in the ventral periaqueductal gray (VPAG) to produce arousal. We find in preliminary data that ethanol engages the activation of this pathway, providing a novel potential mechanism through which alcohol can paradoxically drive wake behavior. Thus in the project we propose to explore the mechanisms through which acute and chronic ethanol exposure regulate this VPAG signaling pathway, and to explore the participation of this pathway in acute and chronic alcohol-dependent alterations in sleep-related behaviors.

Transactions

Action Obligated Date
Amendment $519,891
Amendment $506,099
Original award $517,248

Subawards

Subrecipient Amount Awarded
Emory University This subcontract will provide several services that are important components of this project. Dr. Weinshenker will lead the cell-type specific proteomic… $200,470
Christopher Newport University Dr. Darlene Mitrano (Co-I, Christopher Newport University) will be responsible for the work proposed Aim #2.1: Test the hypothesis that chronic ethanol exposure… $158,122

Quick answers

Who received award R01AA031269?

R01AA031269 was awarded to University Of Massachusetts Medical School by National Institute on Alcohol Abuse and Alcoholism (National Institutes of Health) on July 8, 2024.

How much is award R01AA031269 worth?

$1,543,238 has been obligated on R01AA031269.

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