NRF2-ACSS2 axis in alcohol-induced metabolic reprogramming and esophageal pathology
Active Project Grant Awarded Last action
- Award ID
- R01AA030026
- Recipient
-
Coriell Institute For Medical Research, Inc. UEI XQJNZNQZAFP3
- Awarding agency
-
National Institute on Alcohol Abuse and Alcoholism
National Institutes of Health, Department of Health and Human Services
- Obligated
- $2,933,445
Award facts
- Assistance listing
- 93.273 Alcohol Research Programs
- Completion date 86% complete
- Place of performance
- Camden, NJ 08103, USA
Award details come from USAspending.gov.
Description
- Abstract
- This multiple-PI R01 proposal is designed to incorporate both in vitro and in vivo approaches to elucidate the role of the NRF2-ACSS2 axis in alcohol-induced metabolic reprogramming and esophageal pathology. We hypothesize that the NRF2-ACSS2 axis mediates metabolic reprogramming in alcohol-associated esophageal pathology. We will test this hypothesis using human cells and genetically modified mice through three independent and complementary specific aims. In aim 1, we will characterize the role of NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in human esophageal squamous epithelial cells in vitro. In aim 2, we will validate the role of the NRF2-ACSS2 axis in mediating alcohol-induced metabolic reprogramming in mouse esophagus in vivo. In aim 3, we will examine the inhibitory effects of NRF2 and ACSS2 inhibitors on alcohol-induced metabolic reprogramming and esophageal pathology in vivo. If the hypothesis proved to be true, these studies will lay down a solid mechanistic foundation for NRF2/ACSS2 inhibition as a novel mechanism-based preventive measure against alcohol-associated esophageal pathology in the future.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $574,358 | |
| Amendment | $579,108 | |
| Amendment | $589,786 | |
| Amendment | $616,892 | |
| Amendment | $573,301 | |
| Amendment | -$573,301 | |
| Original award | $573,301 |
Quick answers
Who received award R01AA030026?
R01AA030026 was awarded to Coriell Institute For Medical Research, Inc. by National Institute on Alcohol Abuse and Alcoholism (National Institutes of Health) on July 28, 2022.
How much is award R01AA030026 worth?
$2,933,445 has been obligated on R01AA030026.
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