Project Grant R01AA010030

This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, is focused on determining the relationship between rapid ethanol tolerance and sleep regulation in Drosophila (fruit fly) models. The $215,159 award, spanning September 1, 2024 to August 31, 2026, will support three key experiments: 1) mapping rapid ethanol tolerance in sleep circuitry, 2) investigating the labile and...

This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will provide $221,375 to Oregon Health & Science University (OHSU) to investigate the role of the anterior olfactory system in regulating alcohol consumption. The key objectives are to examine whether chemogenetic activation of oxytocin receptor (OXTR)-containing neurons in the anterior olfactory nucleus (AON) and vasopressin...

The federal Project Grant award R01AA031609, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), is providing $407,060 to The Johns Hopkins University to conduct research on the neural circuit effects of chronic alcohol exposure. The key objectives are to: Characterize changes in neural activity within the anterior cingulate cortex, orbitofrontal cortex, and dorsomedial striatum of rats exposed to chronic alcohol, as they...

This $594,760.84 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research by The Medical University of South Carolina to investigate the role of serotonin receptor signaling in the lateral habenula and its impact on alcohol-induced social deficits. The research aims to characterize how binge alcohol consumption alters the physiological and translational landscape of serotonin 2C...

This $156,204 Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the role of BNST PKCdelta neurons in compulsive ethanol intake behaviors. The research aims to: 1) Evaluate adaptations in BNST PKCdelta neuron calcium transients across an abstinence period during operant behavior; 2) Dissect population dynamics in BNST PKCdelta calcium transients in response to ethanol...

This Project Grant award of $148,880 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to investigate the neural circuit mechanisms underlying impulsivity and how they are altered by genetic risk for excessive drinking. The award will fund experiments to characterize the role of parvalbumin (PV) inhibitory interneurons in the dorsomedial prefrontal cortex (DMPFC) in facilitating strategy updating during a...

This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, provides $499,442 in funding to The Regents of the University of California, San Francisco (UCSF) from August 20, 2024 through July 31, 2027. The award supports research to investigate the role of brain-derived neurotrophic factor (BDNF) signaling in the ventral hippocampus and its contribution to the acute anxiolytic and social...

This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program, aims to investigate the mechanisms by which alcohol disrupts astrocytic control of neuronal excitability. The $146,816 award to The University of Texas Health Science Center at San Antonio will fund research with the following key objectives: Determine if astrocytic FOLH1 contributes to neuronal hyperexcitability during...

This $711,808 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a multi-year research project at Yale University to investigate the neural mechanisms underlying the stress response and its relationship to chronic alcohol consumption. The key objectives of the research are to: 1) develop a connectome-based model to predict stress responses using functional MRI data, 2) characterize dynamic...

This Project Grant award for $545,282 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate neural mechanisms associated with cognitive reappraisal and alcohol cue reactivity in individuals with alcohol use disorder (AUD) during early abstinence. The key objectives are to: 1) determine how neural mechanisms related to reappraisal and alcohol cue-reactivity change across early abstinence...