Project Grant R00ES035871
- The National Institute of Environmental Health Sciences awarded Florida International University $489,258 on April 24, 2026, under the Environmental Health program (CFDA 93.113) to investigate the crosstalk of epitranscriptomic RNA modifications and DNA damage repair mechanisms, with performance through March 31, 2031, at the Miami, Florida campus. The research examines how environmentally induced RNA damage, the epitranscriptomic mark N6-methyladenosine (M6A), and DNA base damage interact on...
- The National Institute of Environmental Health Sciences awarded the Board of Regents of the University of Nebraska $1,479,178 on September 9, 2025, under the Environmental Health program (CFDA 93.113) to quantify the release of nano- and microplastics from plastic food containers into water and beverages and assess potential health risks. The project measures the release of nano- and microplastics from reusable plastic cups, single-use water and soft drink bottles, and takeaway coffee cups...
- The National Institute of Environmental Health Sciences awarded The University of Chicago $735,782 on July 10, 2026, under the Environmental Health program (CFDA 93.113) to conduct research on chromatin regulation through RNA demethylation in environmental stress response. The project investigates N6-methyladenosine (M6A) modifications on messenger RNA and chromatin-associated RNA, focusing on how FTO and ALKBH1 demethylases regulate these modifications in response to environmental stressors...
- The National Institute of Environmental Health Sciences, a component of the Department of Health and Human Services National Institutes of Health, awarded the University of Texas at Austin $415,906 on June 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how air pollution induces shifts in the RNA modification landscape and how pseudouridine-incorporating enzymes relocalize in response to airborne toxins. The research examines whether exposure to ambient air pollution...
- The National Institute of Environmental Health Sciences awarded The Research Foundation For The State University Of New York $814,154 on April 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate epitranscriptomic and epigenetic loops driving cellular responses to naphthalene, a respiratory toxicant and abundant component of wood smoke. The research defines the interplay between epitranscriptomic marks—RNA-based modifications regulating translation—and epigenetic...
- The National Institute of Environmental Health Sciences awarded the University of Kansas Medical Center Research Institute $249,000 on September 11, 2025, under the Environmental Health program (CFDA 93.113) to support research on the dynamics of oxidative DNA demethylation in chromatin. The award funds a mentored career development project (K99/R00 award R00ES036599) that investigates how chromatin structure affects the efficiency of active DNA demethylation by TET2 and thymine DNA...
- The National Institute of Environmental Health Sciences awarded $156,000 to the University of South Alabama on August 5, 2026, to develop and characterize novel single-domain antibodies (nanobodies) tailored to the NEIL1 and NEIL2 DNA glycosylases under the Environmental Health program (CFDA 93.113). The project addresses barriers to studying NEIL1 and NEIL2, which are central to the base excision repair pathway that protects genome integrity from oxidative DNA damage. These enzymes are...
- The National Institute of Environmental Health Sciences, part of the National Institutes of Health under the Department of Health and Human Services, awarded the University of Pittsburgh $127,384 on September 11, 2025, under the Environmental Health program (CFDA 93.113) for research into the dynamics of oxidative DNA demethylation. The award supports a mentored K99/R00 career development grant. During the mentored K99 phase, the candidate will receive training in multiple techniques including...
- The National Institute of Environmental Health Sciences awarded Ohio University $404,163 on August 7, 2026, under the Environmental Health program (CFDA 93.113) to survey Type I nuclear receptor activation by environmental toxins, specifically endocrine-disrupting chemicals and nanoplastics. Ohio University will develop and deploy the FLASH-ER assay, a fluorescence-based laboratory method employing bipartite tetracysteine display and biarsenical profluorophore technology to monitor...
- The National Institute of Environmental Health Sciences awarded $240,000 to the University of Texas at Austin on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate how environmental metals including nickel and cadmium alter DNA and chromatin structures and gene expression. The research will determine the effects of metal exposure and cytosine methylation on non-B DNA formation, chromatin assembly, and gene expression in mammalian cells. The project...
The National Institute of Environmental Health Sciences awarded the Board of Regents of the University of Nebraska $249,000 on September 1, 2026, under the Environmental Health program (CFDA 93.113) to investigate roles for oxidative guanine damage in transcription regulation. The recipient, operating through its University of Nebraska Medical Center division in Omaha, Nebraska, will conduct research on how 8-oxoguanine (8-oxog) lesions—oxidative DNA damage arising from reactive oxygen species generated by environmental exposures such as air pollution, chemicals, and smoking—affect transcriptional responses in cells. The work focuses on mechanisms by which 8-oxog formation and base-excision-repair processing at guanine-rich genomic regions, particularly at telomeres and gene promoters, regulate gene expression in response to oxidative genotoxic damage. The recipient has developed and will deploy a fluorogen activating peptide (FAP) system that produces singlet oxygen when bound to a photosensitizer dye and excited with far-red light, converting guanine to 8-oxog with high spatial and temporal control. During the R00 (Independent Research) phase of this award, the recipient will test whether 8-oxog processing at promoter sequences and genome-wide modulates transcriptional responses to oxidative stress, building on validation work completed during a prior mentored phase. The period of performance runs from September 1, 2026, through August 31, 2029. Place of performance is Omaha, Nebraska.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/24/26 |