Project Grant Q184A080196

This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Massachusetts General Hospital a $735,930 Project Grant (R34) on September 23, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop, validate, and conduct an open trial of a large language model (LLM)-based conversational agent for delivering brief alcohol interventions to emerging adults ages 18-29. The project, which runs through August 31, 2028, addresses the critical public health need to expand screening...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $399,048 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Rochester Institute of Technology (RIT) to examine behavioral and electrophysiological cue reactivity in young adult binge drinkers. The study will compare responses to uni- and multisensory alcohol and neutral cues that vary in degree of realistic appearance, and explore the effects of multisensory congruence on cue responses. The project...

Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Massachusetts General Hospital $226,125 on May 11, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a pilot randomized controlled trial examining phosphatidylethanol (PETH)-based contingency management for alcohol use disorder in patients with alcohol-associated liver disease (ALD). The research project, titled "REINFORCE Trial," will deliver a 12-week behavioral...

Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded RTI International a Project Grant totaling $901,666 on September 20, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop small molecule modulators of RXFP3 (relaxin family peptide receptor 3) as a novel pharmacological treatment for alcohol use disorder (AUD). The project, which extends through June 30, 2030, focuses on optimizing first-in-class nonpeptide, brain-penetrant...

Federal Grant Award Summary Brown University received a $733,137 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), effective September 18, 2025, with a completion date of August 31, 2030. The award funds a 12-week, double-blind, randomized controlled trial (RCT) evaluating probenecid as a pharmacological intervention for alcohol use disorder (AUD). The study will enroll 120 individuals with AUD and test...

Federal Project Grant Award Summary RTI International received a $711,938 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 20, 2025, with completion targeted for August 31, 2030. The grant funds a Type 1 Hybrid Implementation Effectiveness Cluster Randomized Trial evaluating BIPAS (Better Informed Parents Keeping Adolescents Safe from Alcohol), a mobile health intervention designed to prevent...

Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a Project Grant of $720,043 to The Research Foundation For The State University Of New York (doing business as SUNY at Binghamton) under the Alcohol Research Programs (CFDA 93.273) for a randomized clinical trial examining the efficacy of eCheckup to Go (ECTG) combined with a brief parent-based intervention to reduce high school student drinking. The four-year project, awarded September 23, 2025,...

Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Massachusetts General Hospital $734,468 on September 23, 2025, under the Alcohol Research Programs (CFDA 93.273) to develop and pilot Social Identity Mapping for Adolescents in Recovery (SIM-AIR), a novel adjunctive intervention module addressing adolescent alcohol use disorder (AUD). The project, which runs through August 31, 2028, will finalize a standardized treatment intervention that...

Federal Project Grant Award Summary Boston University Medical Campus received a $1.74M Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 17, 2025, with completion targeted for August 31, 2028. The award funds a comprehensive research evaluation assessing the associations between state alcohol taxation policies, policy environments, and alcohol use disorder (AUD) health service outcomes. The...