Project Grant Q184A080119

This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $399,048 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Rochester Institute of Technology (RIT) to examine behavioral and electrophysiological cue reactivity in young adult binge drinkers. The study will compare responses to uni- and multisensory alcohol and neutral cues that vary in degree of realistic appearance, and explore the effects of multisensory congruence on cue responses. The project...

Federal Grant Award Summary Award Details: Funding Agency: National Institute on Alcohol Abuse and Alcoholism (NIAAA) Federal Grant Program: Alcohol Research Programs (CFDA 93.273) Award Amount: $1,759,221 Award Date: September 20, 2025 Project Completion Date: June 30, 2030 Awardee: Research Triangle Institute (RTI International) Performance Location: Research Triangle Park, Durham, NC Scope of Work: RTI International will develop small-molecule negative allosteric modulators (NAMs) targeting...

Federal Project Grant Award Summary RTI International received a $711,938 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 20, 2025, with completion targeted for August 31, 2030. The grant funds a Type 1 Hybrid Implementation Effectiveness Cluster Randomized Trial evaluating BIPAS (Better Informed Parents Keeping Adolescents Safe from Alcohol), a mobile health intervention designed to prevent...

Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded Massachusetts General Hospital (The General Hospital Corporation) a Project Grant of $226,125 on May 11, 2026, to conduct a pilot randomized controlled trial evaluating phosphatidylethanol (PETH)-based contingency management for alcohol use disorder in patients with alcohol-associated liver disease (ALD). The primary deliverable is the REINFORCE Trial, a 12-week intervention study comparing...

Federal Project Grant Award Summary Boston University Medical Campus received a $1.74M Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), awarded September 17, 2025, with completion targeted for August 31, 2028. The award funds a comprehensive research evaluation assessing the associations between state alcohol taxation policies, policy environments, and alcohol use disorder (AUD) health service outcomes. The...

Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $632,070 on September 16, 2025, to The Research Foundation for the State University of New York to conduct a Phase 2 randomized controlled trial examining the efficacy of the Protecting Allies in Risky Situations (PAIRS) motivational interviewing intervention. This research initiative, supported under the Alcohol Research Programs (CFDA 93.273), addresses alcohol-involved sexual assault...

Federal Grant Award Summary Real Recovery VR, Inc. received a $928,356 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to develop a virtual reality (VR) platform designed to enhance counselor-delivered treatment for alcohol use disorder (AUD). The platform addresses a critical treatment gap by providing immersive, simulation-based training that helps patients develop and practice coping skills in...

Federal Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded the University of North Carolina at Chapel Hill a Project Grant of $444,576 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct a preclinical screening pipeline evaluating glucagon-like peptide-1 receptor agonist (GLP-1RA) compounds for their potential therapeutic effects on alcohol use disorder (AUD). The research will assess three FDA-approved or investigational...

Federal Project Grant Award Summary The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded $497,962 to the University of California, San Diego on September 15, 2025, for a three-year research project extending through August 31, 2028. The funded research investigates the role of gut microbial ethanol production in alcohol use disorder (AUD) and alcohol-associated liver disease (AALD). The project focuses on characterizing the...