Project Grant Q184A070088

This $673,500 Project Grant from the National Institutes of Health's National Institute on Alcohol Abuse and Alcoholism will fund Amygdala Neurosciences, Inc. to develop new, potent, selective, and reversible inhibitors of aldehyde dehydrogenase 2 (ALDH2) for the treatment of alcohol use disorder. The goal is to implement an innovative screening technology to discover novel compounds that reduce craving and alcohol consumption by selectively inhibiting ALDH2 in a reversible manner, avoiding...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $1,742,166 Project Grant under CFDA 93.273 - Alcohol Research Programs to the Trustees of Boston University, doing business as Boston University Medical Campus. The grant supports a comprehensive evaluation to assess the associations of state alcohol taxation and related policy environment with state-level alcohol treatment facilities capacity and key alcohol use disorder (AUD) health service outcomes. The project...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $498,002 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Illinois to conduct a study aimed at increasing alcohol abstinence in young adults with alcohol use disorder (AUD). The overall goals of this 3-year project are to: (1) test the efficacy of combining contingency management (CM) with problem-solving therapy (CM-PST) versus CM alone in a 2-arm pilot randomized controlled trial, and...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $399,048 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Rochester Institute of Technology (RIT) to examine behavioral and electrophysiological cue reactivity in young adult binge drinkers. The study will compare responses to uni- and multisensory alcohol and neutral cues that vary in degree of realistic appearance, and explore the effects of multisensory congruence on cue responses. The project...

This Project Grant award, totaling $755,539, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The funding will support research conducted by Emory University to evaluate the real-world utilization, effectiveness, and safety of glucagon-like peptide-1 receptor agonists (GLP-1RAs) as a treatment for alcohol use disorder (AUD). The project aims to leverage administrative claims data and linked electronic health records...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $390,454 Project Grant to Envisbio LLC to develop novel therapeutic aptamers targeting phosphodiesterase 4B (PDE4B) for the treatment of alcohol use disorder (AUD). The project aims to identify and characterize PDE4B-specific aptamers that can modulate PDE4B activity, with the goal of advancing these modulators into in vivo testing and eventual human clinical trials for...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $309,452 Project Grant to Real Recovery VR, Inc. on Sep 15, 2025. The award supports the development of a virtual reality (VR) platform that counselors can use to enhance treatment techniques and improve outcomes among those with alcohol use disorder (AUD). The project aims to leverage VR technology to provide patients with opportunities to practice coping skills in...

The National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), awarded a $901,666 Project Grant to Research Triangle Institute (RTI International) to develop small molecule modulators of the RXFP3 receptor as potential therapeutic agents for alcohol use disorder (AUD). The project aims to further optimize and evaluate the effectiveness of the RXFP3 negative allosteric modulators (NAMs) RLX-33 and RLX-79 in animal models of alcohol...

This Project Grant award of $175,372 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports a training program in the etiology and consequences of alcohol use across the lifespan at the Rutgers Addiction Research Center (RARC), the largest comprehensive addiction research center in the U.S. The interdisciplinary training program, led by 11 RARC-affiliated faculty mentors, will provide postdoctoral trainees with expertise in the...

This $302,024 Project Grant was awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the federal Alcohol Research Programs (CFDA 93.273) on September 14, 2023. The grant supports a research project by the Research Foundation of the City University of New York (RFCUNY) to assess the impacts of increased alcohol home delivery during the COVID-19 pandemic. The project aims to: 1) document compliance with age verification policies during alcohol home deliveries, 2)...