Vanderbilt AUD research and education center (varec)

Active Project Grant Awarded Last action

Award ID
P60AA031124
Recipient
Awarding agency
Obligated
$8,922,533

Award facts

Assistance listing
93.273 Alcohol Research Programs
Completion date 53% complete
Place of performance
Nashville, TN 37203, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
The central thesis of the vanderbilt AUD research and education center (varec) is that effective treatment requires recognition of, and deep understanding of the diverse symptoms, etiologies, and disease progressions that underlie what is unitarily referred to as alcohol use disorder (AUD). We propose a reverse translational "precision neuroscience" approach. We will dissect AUD endophenotypes to generate human circuit construct validated animal models that we will utilize to gain mechanistic insights and test therapeutic targets. Varec will consist of 4 research components (PROJECTS1-4) supported by administrative and research cores, as well as a dissemination core. Project 1 (blackford) expands our initial human imaging studies into a deep sampling approach to analyze bnst and network connectivity in AUD across the abstinence timespan, exploring individual differences in these networks with AUD relevant domains such as anxiety and depression. Project 2 (winder) will build off an already active collaboration with project 1 to perform reverse translational mouse studies to test emergent hypotheses on insula-bnst and hippocampal-bnst connectivity in mouse models of AUD, and to explore potential time-dependent therapeutic approaches during abstinence. Project 2 will also perform specific broad-scale mouse brain imaging studies to define network nodes for project 1 to explore in years 4-5. Project 3 (calipari) will explore whether alterations in negative affect observed in project 1 and project 2 lead directly to functional enhancement of negative reinforcement-oriented circuitries and behavior. Finally, project 4 (siciliano) will engage in deep phenotyping of individual differences in mouse behaviors correlated with compulsive drinking behavior, working across the projects to identify populations of precise behaviors that are predictive of compulsive ethanol seeking. Projects 2 and 4 explore therapeutic targets through analysis of endocannabinoid and dynorphin signaling. The project interactions will be coordinated by an administrative core. A research core will provide mice that have undergone one of two voluntary alcohol exposure models, chronic drinking-forced abstinence (cdfa) or structured tracking of alcohol reinforcement (star). IT will also provide research infrastructure and computational support. Through a dissemination core, varec will play an important role in public health by activities aimed at destigmatizing AUD treatment seeking and increasing prevention through novel near-peer targeting of adolescents. This core will also allow varec to serve as a resource to the alcohol research community to facilitate mainstream incorporation of cutting-edge tools into the field.

Transactions

Action Obligated Date
Amendment $1,751,604
Amendment $0
Amendment $0
Amendment $1,780,382
Amendment $1,780,382
Amendment Vanderbilt AUD research and education center (varec) - the central thesis of the vanderbilt AUD research and education center (varec) is that effective… $1,780,382
Original award $1,829,783

Subawards

Subrecipient Amount Awarded
Vanderbilt University Medical Center Our multidisciplinary application is aimed at determining kappa opioid receptor regulation of periaqueductal gray (PAG) action. OP Co-PI will be responsible for… $41,769
University Of Nebraska Medical Center OP PI will be responsible for all aspects of Project 1 including study questions and hypotheses, study design, data collection, data interpretation, and… $450,605
University Of Massachusetts Medical School We will perform the research outlined in project 2 exploring specific circuits and molecules involved in AUD relevant behaviors in mouse models. $268,802
University Of Massachusetts Medical School The admin core will oversee and coordinate research and administrative activities of the center. $65,404
University Of Massachusetts Medical School We will perform the research outlined in project 2 exploring specific circuits and molecules involved in AUD relevant behaviors in mouse models. -$5,028
University Of Massachusetts Medical School The admin core will oversee and coordinate research and administrative activities of the center. -$1,133
University Of Nebraska Medical Center OP PI will be responsible for all aspects of Project 1 including study questions and hypotheses, study design, data collection, data interpretation, and… -$3,476
University Of Nebraska Medical Center $180,481
University Of Massachusetts Medical School The admin core will oversee and coordinate research and administrative activities of the center. $9,104
University Of Nebraska Medical Center In her role as Associate Director of VAREC, Dr. Blackford will work closely with Dr. Winder to lead the Administrative Core of VAREC. Drs. Winder and… $35,214
University Of Nebraska Medical Center OP PI will be responsible for all aspects of Project 1 including study questions and hypotheses, study design, data collection, data interpretation, and… $388,387
University Of Massachusetts Medical School We will perform the research outlined in project 2 exploring specific circuits and molecules involved in AUD relevant behaviors in mouse models. $282,306
University Of Massachusetts Medical School The admin core will oversee and coordinate research and administrative activities of the center. $64,868
Vanderbilt University Medical Center Our multidisciplinary application is aimed at determining kappa opioid receptor regulation of periaqueductal gray (PAG) action. OP Co-PI will be responsible for… $37,032
Vanderbilt University Medical Center $39,892
University Of Nebraska Medical Center OP PI will be responsible for all aspects of Project 1 including study questions and hypotheses, study design, data collection, data interpretation, and… $351,917
University Of Massachusetts Medical School We will perform the research outlined in project 2 exploring specific circuits and molecules involved in AUD relevant behaviors in mouse models $268,096
University Of Massachusetts Medical School The admin core will oversee and coordinate research and administrative activities of the center. $59,042
Show all 18

Quick answers

Who received award P60AA031124?

P60AA031124 was awarded to Vanderbilt University by National Institute on Alcohol Abuse and Alcoholism (National Institutes of Health) on March 15, 2024.

How much is award P60AA031124 worth?

$8,922,533 has been obligated on P60AA031124.

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