Project Grant P50HD118708
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $900,000 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Children's Hospital Medical Center in Cincinnati, Ohio. This 5-year grant, with a start date of September 18, 2025 and an end date of August 31, 2030, will fund mechanistic and translational research on brain neurophysiology and phenotypic heterogeneity in Fragile X Syndrome (FXS). The research...
- This federal Project Grant award of $430,375.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research on membrane trafficking impairments in Fragile X Syndrome. The research aims to investigate the underlying mechanisms by which the loss of the FMRP protein in Fragile X Syndrome leads to dysregulated surface expression of membrane proteins, which is believed...
- This $836,125.47 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to understand the molecular mechanisms governing lymphatic dysfunction in a mouse model of neurodevelopmental disorder, specifically Fragile X Syndrome (FXS). The research project will: 1) Determine how the FMR1 gene regulates meningeal lymphatic function, 2) Decipher the role of FMR1-induced lymphatic dysfunction in interferon gamma (IFNγ) T...
- This Project Grant award of $425,628.00 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research federal grant program (CFDA 93.865), aims to elucidate the role of the FMR1 gene in regulating reproductive function. The overarching goal is to investigate the molecular mechanisms by which FMR1 gene mutations, which cause Fragile X syndrome and premature ovarian failure, impact ovarian function...
- The University of California, Davis (UC Davis) was awarded a $1,169,064 Cooperative Agreement grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The purpose of this 5-year award is to finalize refinement and validation of a primary clinical outcome assessment, the FXTAS Rating Scale (FXTAS-RS), as well as a set of neurocognitive, motor, and...
- This $160,000 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will support research by Northwestern University to investigate the mechanistic underpinnings of pragmatic language impairments in autism spectrum disorder (ASD) and FMR1 mutation conditions. The research aims to characterize the motor-speech skills contributing to pragmatic...
- The federal Project Grant award of $127,557 from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) supports a research project titled "Brain Aging in Adults with Autism Spectrum Disorder". The goal is to characterize age-related changes in neuroimmune profiles, immune cell phenotypes, and neuronal inflammation in adults with autism spectrum disorder (ASD) compared to unaffected controls using postmortem human brain tissue....
- This federal Project Grant award, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to characterize a genetic mouse model for a gene implicated in neurodevelopmental disorders including autism, intellectual disability, and schizophrenia. The $742,484 award, with a project period from January 13, 2025 to October 31, 2029, will fund experiments to obtain multiome single nucleus RNA-sequencing,...
- This federal Project Grant award of $136,050.00, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), supports research to investigate how a specific protein, BTBD11, regulates the function and composition of glutamatergic synapses in interneurons. The research aims to elucidate the role of BTBD11 and liquid-liquid phase separation in maintaining the unique properties of glutamatergic synapses in interneurons, which are...
- The Washington University Office of Sponsored Research Services Division received a $427,625 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to unravel the role of satellite glial cells in sensory hypersensitivity in Fragile X Syndrome, a leading genetic cause of autism spectrum disorders. Key activities include: Examining how...
This federal Project Grant award of $670,675, granted by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to advance the understanding of the clinical phenotypes and underlying mechanisms associated with Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) and Fragile X-Associated Neuropsychiatric Disorders (FXAND) across the lifespan. The award will support two research projects: Project 1 will identify the developmental trajectory of social communication deficits and their relationship to FXAND in 3 to 5-year-olds with the FMR1 premutation. It will also determine the extent to which auditory processing and molecular-genetic variation predict social communication across age. Project 2 will establish the timing, developmental trajectory, and prodromal language/vocal phenotypes predictive of FXTAS-related motor, cognitive, and psychiatric symptoms in FMR1 premutation women across 35 to 80 years of age. This P50 Center grant aims to characterize the FMR1 premutation phenotype across the lifespan and identify novel mechanisms and targets for intervention through a collaborative, interdisciplinary approach.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $670.7k | 9/10/25 |