Project Grant P30GM138396

This $436,361 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative computational tools and algorithms to advance small-angle and wide-angle X-ray scattering (SWAXS) analysis for studying the structure and dynamics of biological macromolecules. The key objectives of this 5-year project include: 1) Improving the resolution of density reconstructions...

This Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) provides $225,000.00 to Carnegie Mellon University and Purdue University to develop a cyberinfrastructure to support the analysis of cryo-electron tomography (cryo-ET) data. The project will build an open-access, annotated database of cryo-ET images, both simulated and experimentally obtained, alongside a toolbox of computational methods for their analysis. This infrastructure will...

This Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) federal grant program provides $250,000 to the University of California, Davis to develop fast and robust algorithms for 3D molecular structure reconstruction from cryo-electron microscopy (cryo-EM) data. The project aims to overcome the computational barriers limiting the widespread adoption of cryo-EM by creating new algorithms for image alignment and molecular...

This $535,686 National Science Foundation project grant will fund the acquisition of a comprehensive X-ray scattering system for in situ studies at the University of California, Davis through August 2025. The system will transform research, education, and outreach in materials characterization across California's Central Valley under the Mathematical and Physical Sciences program (CFDA 47.049). Specifically, the state-of-the-art instrument serves as a flagship tool for advanced materials...

The National Science Foundation awarded a $279,990 Project Grant to the University of California, Merced under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to acquire a dual-source single crystal x-ray diffractometer. The diffractometer will be used by Professor Michael Findlater and colleagues to determine the precise three-dimensional molecular structures of organic and inorganic compounds, materials, and biomolecules through x-ray crystallography. This will...

The University of Pittsburgh received a $308,651 Project Grant from the National Science Foundation to acquire a single crystal x-ray diffractometer for research and education. Funded under the NSF's Mathematical and Physical Sciences program (CFDA 47.049), the award will support the research of Professor Raul Hernandez Sanchez and Nathaniel Rosi through the acquisition of a dual-source diffractometer equipped with copper and molybdenum x-ray sources, an enhanced detector, and cryogenic...

The National Institute of General Medical Sciences (NIGMS) awarded a $202,467 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Acpharis, a biotechnology software company based in Holliston, Massachusetts. The grant supports the development of a commercial-quality software product that integrates machine learning with physics-based computational approaches to accurately predict the structures of antibody-antigen complexes. This breakthrough technology,...

This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...

This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...

The National Science Foundation awarded a $213,671 Project Grant to The Research Foundation For The State University Of New York to support the acquisition of a high brilliance dual-source X-ray diffractometer for advanced materials research, education, and training at the State University of New York - Buffalo. The diffractometer and associated research will advance the Mathematical and Physical Sciences program's goals of strengthening the nation's scientific enterprise and increasing...