Project Grant P30GM133893

The New York Structural Biology Center, Inc. has been awarded a $1,995,724 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to acquire a state-of-the-art 800 MHz NMR spectrometer console and associated probes. This instrumentation will enhance the capacity of the existing 800 MHz NMR system to support a range of NIH-funded structural biology research, from fundamental studies of biomolecular...

Under a $12,915,128 Project Grant award from the National Institute of General Medical Sciences (NIGMS), Stanford University and the SLAC National Accelerator Laboratory will continue operating the Stanford-SLAC Cryogenic Electron Microscopy (CryoEM) Center (S2C2) as a national resource to support high-resolution structural biology research. Key services provided include: upgrading and maintaining six cutting-edge CryoEM instruments, assisting users with sample preparation and data...

The National Institute of General Medical Sciences (NIGMS) awarded a $7,709,519 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to The New York Structural Biology Center, Inc. to operate the National Center for CryoEM Access and Training (NCCAT). NCCAT provides nationwide access to state-of-the-art cryo-electron microscopy (cryoEM) instrumentation and expert technical support to enable rapid, high-resolution structural characterization of macromolecules. The award...

This $1,200,000 Project Grant awarded by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) supports research at Columbia University to develop and apply a time-resolved cryo-electron microscopy (cryo-EM) technique. The primary goal is to use this method to study the structural dynamics of diverse biological molecules, including RNA polymerase, GLP1R, and multi-drug efflux transporter AcrB, in collaboration with three partner laboratories. This interdisciplinary...

This $573,147 National Science Foundation Project Grant through the Integrative Activities program (CFDA 47.083) will fund the acquisition of a Zeiss LSM 900 confocal microscope with Airyscan for Queens College of the City University of New York's Core Facility for Imaging, Cell, and Molecular Biology. The microscope will enhance multidisciplinary research and training at the minority-serving institution by enabling new microscopy courses and outreach activities promoting STEM access for...

This Project Grant award from the National Science Foundation (CFDA 47.074 - Biological Sciences) provides $743,852 to Saint Louis University to acquire an XtalLAB Synergy-R single crystal diffractometer. The advanced instrument will enable researchers from Saint Louis University and other regional academic institutions to collect high-quality single crystal diffraction data more efficiently and with reduced energy and water consumption. This new capability will support cutting-edge research...

This Cooperative Agreement award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (MPS) program, CFDA # 47.049, provides $3,166,667 in funding to Cornell University to continue operating the Center for High Energy X-Ray Science (CHEXS) - a national user facility that provides researchers with access to unique, world-leading experimental capabilities for X-ray science. CHEXS consists of four core research efforts, each focused on a specific synchrotron beamline...

The National Institute of General Medical Sciences (NIGMS) awarded a $500,000 Project Grant (CFDA 93.859 Biomedical Research and Research Training) to Rutgers, The State University of New Jersey to manage and deliver the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB). The RCSB PDB works with stakeholders to preserve and provide open access to rigorously validated, expertly curated, three-dimensional biostructure information for millions of depositors and...

The National Institute of General Medical Sciences (NIGMS) awarded a $7,269,009 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Oregon Health & Science University (OHSU) to establish the Pacific Northwest Center for Cryo-EM. The center will provide access to cutting-edge cryo-electron microscopy (cryo-EM) technology and training opportunities to the structural biology community. Specifically, the center will develop and implement new cryo-EM...

The National Science Foundation (NSF) Office of Integrative Activities awarded Brandeis University a 3-year, $1,767,282 Project Grant to acquire a Thermo-Fisher Tundra cryo-electron microscope. This advanced microscope will enable visualization and analysis of complex biological structures at the macromolecular level, fostering interdisciplinary collaboration across fields from materials science to cell biology. The microscope will be available to researchers at Brandeis and in the local...