Early-phase psychosis: practice-based research to improve treatment outcomes

Active Project Grant Awarded Last action

Award ID
P01MH139136
Recipient
Awarding agency
Obligated
$3,162,890

Award facts

Assistance listing
93.242 Mental Health Research Grants
Completion date 29% complete
Place of performance
Manhasset, NY 11030, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Our group has a long-standing commitment to improving care for individuals with first episode psychosis (FEP), e.g. we developed the navigate coordinated specialty care (CSC) treatment model for the raise-ETP study. The current epinet project allowed US to improve FEP care within a learning health system (LHS) framework. Our current esprito epinet has enrolled 963 participants. Our proposed esprito epinet will enroll an additional 625 participants from 13 clinics in 6 states. All sites provide care with the navigate model, serve diverse populations and except for one are community facilities without any academic affiliations. Moving forward, the esprito central team will continue to provide sites the successful supports developed in the current esprito for LHS and research project recruitment, retention, obtaining core assessment battery (CAB) assessments, data management including provision of CAB data to the epinet data coordinating center. Navigate treatment and the LHS model are based upon measurement-based care and we will continue on-going training to site personnel on assessment and the use of assessments to improve care. For the proposed work, we will expand the range of dashboards and means to convey information to sites. Our statistical analyses include innovations both in the methods that will be used and the incorporation of visualization tools to communicate the results to clinicians who may have limited statistical expertise. A novel measure will be used to evaluate social determinants of health (SDOH) to further understand site diversity. Combining data from the current esprito project and the proposed work will also permit analyses of subpopulations of interest (e.g., those of hispanic ethnicity). To enhance sites' ability to improve care the proposed work includes a learning collaborative about overall treatment issues and another about enhancing patient participation in the LHS and in navigate treatment. We will also mentor the next generation of LHS/CSC research and clinical leaders. We will also perform 2 research studies. 1) determine clinical characteristics of individuals who disengage from the LHS or from navigate treatment. Using data that can be obtained during clinical care (e.g. the core assessment battery) we will characterize patient participants who disengage at two levels: those who enroll in the LHS but do not participate in the data collection needed for measurement-based care and those who prematurely terminate all CSC treatment. 2) determine the utility at real world clinics of automated speech and language analysis to identify participants at risk for treatment disengagement or for relapse and hospitalization. Automated speech and language analysis has the potential to provide sites important information about patient status beyond what is obtained by usual clinical measures. In addition to the 2 defined projects, we will also collaborate with other epinet hubs via the epinet research consortium and development of collaborative research projects.

Transactions

Action Obligated Date
Amendment $1,503,322
Original award $1,659,568

Subawards

Subrecipient Amount Awarded
Northwestern University The Northwestern University site will be primarily responsible for oversight of the qualitative data collection, analysis, and interpretation. Dr. Carroll… $6,277
Yale Univ Yale University will perform a needs assessment of the clinical sites, implement, offering hosting and maintenance of the ESPRITO ONE installation (a branch… $95,307
South County Mental Health Center, Inc. The PI/PD will have overall responsibility for the project at the site. This will include confirming monthly recruitment numbers and overseeing that patients… $29,249
The University Of Chicago For the proposed work, Dr. Gibbons will design in conjunction with other ESPRITO key personnel the statistical analysis for the ESPRITO Learning Health… $45,992
Kent County CMH Authority The PI/PD will have overall responsibility for the project at the site. This will include confirming monthly recruitment numbers and overseeing that patients… $149,736
Board Of Regents Of Nevada System Of Higher Education The PI/PD will have overall responsibility for the project at the site. This will include confirming monthly recruitment numbers and overseeing that patients… $51,623
South County Mental Health Center, Inc. The PI/PD will have overall responsibility for the project at the site. This will include confirming monthly recruitment numbers and overseeing that patients… $27,660
The University Of Chicago For the proposed work, Dr. Gibbons will design in conjunction with other ESPRITO key personnel the statistical analysis for the ESPRITO Learning Health… $44,216
South County Mental Health Center, Inc. The Northwestern University site will be primarily responsible for oversight of the qualitative data collection, analysis, and interpretation. Dr. Carroll… $0
Kent County CMH Authority The PI/PD will have overall responsibility for the project at the site. This will include confirming monthly recruitment numbers and overseeing that patients… $139,840
Board Of Regents Of Nevada System Of Higher Education The PI/PD will have overall responsibility for the project at the site. This will include confirming monthly recruitment numbers and overseeing that patients… $49,982
Yale Univ Yale University will perform a needs assessment of the clinical sites, implement, offering hosting and maintenance of the ESPRITO ONE installation (a branch… $127,302
Oregon Research Institute Early-PhasePsychosis:Practice-BasedResearchtoImproveTreatmentOutcomes $74,982
Show all 13

Quick answers

Who received award P01MH139136?

P01MH139136 was awarded to The Feinstein Institutes For Medical Research by National Institute of Mental Health (National Institutes of Health) on June 2, 2025.

How much is award P01MH139136 worth?

$3,162,890 has been obligated on P01MH139136.

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