Mdro carriage, transmission, sequelae, and prevention in nursing homes

Active Project Grant Awarded

Award ID
P01AI172725
Recipient
Awarding agency
Obligated
$2,853,098

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date 69% complete
Place of performance
Irvine, CA 92697, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Overview: mdro carriage, transmission, sequelae, and prevention in nursing homes this P01 program proposal will address critically important questions surrounding the expanding problem of multidrug-resistant organisms (MDROS) in nursing homes (NH). Of the 1.4 million residents residing annually in 15,000 U.S. NHS, more than half (65%) are estimated to harbor MDROS. These MDROS not only impact medically vulnerable residents in NHS, but they can spread to surrounding hospitals and long-term care facilities, causing significant morbidity and mortality. Despite growing evidence that NHS are major reservoirs of MDROS, investments to address MDROS in this health sector are lacking. Little is known about sources or drivers of mdro transmission, and identification of effective interventions is needed. This program integrates expertise in infectious diseases, epidemiology, microbiology, pathogen genomics, human microbiome, statistics, systems science, health economics, and agent-based models to conduct an unprecedented set of studies on five MDROS in NHS - methicillin-resistant staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), extended-spectrum beta-lactamase producers (ESBLS), carbapenem-resistant enterobacterales (CRE) and the newly-emerged resistant fungus, candida auris. By leveraging previous and newly-conducted studies, this program will provide one of the largest compilations of mdro isolates from NH residents and environmental fomites. A total of 16,000 mdro isolates and 3,000 metagenomic samples from 50 NHS will be studied using epidemiology, genomics, and simulation modeling as distinct and synergistic vantage points to elucidate 1) best sampling methods for mdro carriage and CO- carriage, 2) key sources and drivers of mdro transmission, 3) major risk factors associated with carriage, infection, and hospitalization, and 4) high-yield interventions to inform infection prevention policies to mitigate adverse health outcomes due to MDROS in NHS.

Subawards

Subrecipient Amount Awarded
The Broad Institute, Inc. During Year 1 - Year 5 of this project, the role of the Broad Institute is to i) perform DNA extraction and metagenomic sequencing of 200 rectal swabs; ii)… $396,017
The Broad Institute, Inc. The role of the Broad Institute is to i) build robust, shareable, cloud-based analysis pipelines within the Broad Institute’s Terra Platform, working closely… $205,509
Research Foundation Of The City University Of New York Dr. Bruce Y. Lee, as PI, along with his team will lead the development of computational simulation models to simulate the simultaneous transmission of five… $520,604
The Broad Institute, Inc. The role of the Broad Institute is to i) build robust, shareable, cloud-based analysis pipelines within the Broad Institute’s Terra Platform, working closely… $0
Research Foundation Of The City University Of New York Carryover approval for the amount of $172,065 from budget period 07/11/2023-04/30/2025 into budget period 05/01/2025-04/30/2026. $0
The Broad Institute, Inc. The role of the Broad Institute is to i) build robust, shareable, cloud-based analysis pipelines within the Broad Institute’s Terra Platform, working… $236,010
The Broad Institute, Inc. Statement of Work - The Broad Institute During Year 1 - Year 5 of this project, the role of the Broad Institute is to i) perform DNA extraction and… $365,712
The Broad Institute, Inc. The role of the Broad Institute is to i) build robust, shareable, cloud-based analysis pipelines within the Broad Institute’s Terra Platform, working… $267,230
Research Foundation Of The City University Of New York Dr. Bruce Y. Lee, as PI, along with his team will lead the development of computational simulation models to simulate the simultaneous transmission of five… $505,663
University Of Massachusetts SCOPE OF WORK FOR PROJECT 1 COMPONENT Dr. Kleinman is Professor and Associate Chair in the Department of Biostatistics and Epidemiology at the University of… $80,975
University Of Massachusetts SCOPE OF WORK FOR DATA SCIENCES & STATISTICAL CORE Dr. Kleinman is Professor and Associate Chair in the Department of Biostatistics and Epidemiology at the… $31,273
Show all 11

Quick answers

Who received award P01AI172725?

P01AI172725 was awarded to University Of California Irvine by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on July 11, 2023.

How much is award P01AI172725 worth?

$2,853,098 has been obligated on P01AI172725.

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