Project Grant OT3HL142478

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $1,609,964 to The Regents of the University of California, San Francisco on July 25, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate genetic ancestry effects on molecular and complex traits within the Trans-Omics for Precision Medicine (TOPMED) project. This Project Grant supports research utilizing TOPMED's Freeze 10 cohort of 180,852 individuals with whole genome...

The National Institutes of Health's Office of the Director awarded a $8,661,331 project grant under the Lung Diseases Research program (CFDA 93.838) to the Massachusetts General Hospital on June 10, 2021 for the development of interactive data portals and analytic tools to support Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) cohorts. Key products and services delivered through Massachusetts General Hospital and several sub-awardees include an interactive data portal called the...

The University of Virginia received a $2.31 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for May 31, 2029. The grant funds development and application of MetaBoxcan, an innovative computational method that integrates genome-wide association studies (GWAS), gene expression data, and metabolomics to elucidate the molecular pathophysiology of...

Federal Grant Award Summary Award Details: The National Heart, Lung, and Blood Institute (NHLBI) awarded Brigham and Women's Hospital a $818,279 Project Grant effective September 1, 2025, through May 31, 2029, under the Cardiovascular Diseases Research program (CFDA 93.837). The project, titled "Leveraging Research and Clinical Cohorts to Improve Obstructive Sleep Apnea Subtyping," addresses critical gaps in obstructive sleep apnea (OSA) diagnosis and treatment prediction by developing...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Wisconsin-Madison a $747,262 Project Grant (CFDA 93.837: Cardiovascular Diseases Research) effective June 1, 2026 through February 28, 2030 to advance precision medicine approaches for phospholamban-induced dilated cardiomyopathy (DCM). The research project will employ top-down proteomics technology to characterize the multi-omics landscape of phospholamban-R14 deletion...

Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded Tufts University School of Medicine a $1.12 million Project Grant (CFDA 93.837, Cardiovascular Diseases Research) on September 17, 2025, to conduct a multiethnic and multiomics analysis of longitudinal changes in DNA methylation (DNAM) and cardiovascular health. The four-year research initiative, concluding July 31, 2029, integrates longitudinal epigenome-wide DNAM data with behavioral, clinical, genetic,...

Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Leland Stanford Junior University a Project Grant totaling $192,672 (awarded August 1, 2025, with completion scheduled for July 31, 2030) under the Cardiovascular Diseases Research program (CFDA 93.837) to conduct an investigation of omics for bronchopulmonary dysplasia (BPD). The research will deliver three primary outputs: (1) identification of distinct lipid and metabolomic profiles...

Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant of $5.96 million to The Children's Hospital Corporation (Boston Children's Hospital) under the Cardiovascular Diseases Research program (CFDA 93.837). Initiated on August 15, 2025, and extending through May 31, 2030, this award funds "Optimizing HCT Outcomes: A Multi-Omic Investigation," a research initiative addressing hematopoietic stem cell transplantation (HCT) outcomes in...

Federal Project Grant Award Summary The University of Michigan received a $1,380,474 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 24, 2025, with completion targeted for July 31, 2027. The OPTIBED (Optimizing the Care of Acute Heart and Lung Diseases through Precision Triage and Inpatient Bed Assignment) project addresses preventable hospital mortality by developing data-driven clinical...

Federal Project Grant Award Summary Brigham & Women's Hospital Inc. received a $268,500 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for June 30, 2028. The award funds a research project titled "Using Multi-Omic and Network Analysis to Understand Gene Dosage Effect in COPD," which will generate comprehensive scientific findings on the role...