Project Grant NNJ04HC90G

Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded The Children's Hospital of Philadelphia (CHOP) a Project Grant totaling $719,498 (awarded August 1, 2025; completion July 31, 2030) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). This research project investigates the neurological pathophysiology of disrupted O-glycosylation in congenital disorders of glycosylation (CDG),...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, will fund research to target cell-scaffolding proteins that contribute to radioresistance in glioblastoma, an aggressive brain cancer. The $448,250 award to The Research Foundation For The State University Of New York, operating as Upstate Medical Center, will support a 2-year...

Federal Project Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $489,500 Project Grant award, effective May 1, 2026, through the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The two-year research initiative investigates the molecular mechanisms underlying BLOC1S1-related leukoencephalopathy, a rare neurological condition...

FEDERAL GRANT AWARD SUMMARY Cincinnati Children's Hospital Medical Center received a $803,958 Project Grant award (announced July 23, 2025) from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award supports research and development of an innovative nanocarrier-based therapeutic delivery system designed to treat neuronopathic Gaucher disease (NGD), a severe...

This Project Grant award of $414,191 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will fund research by Drexel University investigating the relationship between structural variations in alpha-synuclein (α-syn) protein fibrils and the development of distinct neurodegenerative synucleinopathies such as Lewy body dementia, Parkinson's disease, and multiple system atrophy....

This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,625,947 to the University of Rochester to conduct research on the relationship between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives are to evaluate whether ambient and subway-level iron exposure leads to...

Federal Grant Award Summary Case Western Reserve University (CWRU) received a Project Grant award of $442,750 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective August 1, 2025, through July 31, 2027. The research focuses on elucidating the role of CCPG1, an endoplasmic reticulum (ER)-phagy receptor, in maintaining proteostasis of gamma-aminobutyric acid...

Federal Grant Award Summary Boston Children's Hospital received a $489,500 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), effective March 1, 2026, through February 29, 2028. The award funds basic neuroscience research investigating the mechanistic relationship between cerebrospinal fluid (CSF) glutamate levels and choroid plexus blood-CSF barrier...

This Project Grant award, totaling $101,668.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award supports research to investigate the role of the PANX1 ion channel in cortical development and its potential contribution to the pathogenesis of polymicrogyria, a malformation of the cerebral cortex. Key objectives include...

This $438,342 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to study the fundamental mechanisms by which ubiquitin ligases recognize and ubiquitinate substrates within protein complexes. The research focuses on understanding the role of the anaphase-promoting complex (APC) in regulating the composition of neuronal...