Project Grant N629092412035

This $673,512 Project Grant awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research by the University of California, San Francisco (UCSF) to investigate the neural mechanisms underlying breathing rhythms. The project aims to determine whether the subconscious breathing rhythm arises from an autonomous oscillator or reciprocal inhibition between key neuronal populations in the brainstem. UCSF will use advanced mouse...

The University of California, Los Angeles (UCLA) was awarded a $721,237 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to investigate the neural mechanisms by which inspiratory muscle training (IMT) can reduce blood pressure in patients with obstructive sleep apnea. The research project will use resting-state functional magnetic resonance imaging and magnetic resonance spectroscopy to assess changes in insula connectivity and...

This Project Grant award of $497,628.00 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into pulmonary vagal sensory neurons and their role in breathing abnormalities associated with bronchopulmonary dysplasia (BPD) in preterm infants. The research aims to elucidate the dose- and duration-dependent effects of neonatal hyperoxia exposure on breathing control and the functional roles of distinct populations of...

This federal Project Grant award, valued at $744,305 and awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), supports a research project titled "Molecular Physiology of PHOX2B-Expressing RTN Chemoreceptor Neurons" at the University of Virginia. The research examines gene regulatory functions of the PHOX2B transcription factor and its relevance for the function and connectivity of retrotrapezoid nucleus...

The National Science Foundation (NSF) awarded a $1,363,205 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of California, San Diego (UCSD) to conduct collaborative research on oxygen transport mechanisms in elite diving mammals. The project aims to investigate differences in how oxygen is delivered to skeletal muscles in pinnipeds (e.g., sea lions) versus cetaceans (e.g., dolphins) during long-duration dives. The research team will evaluate in vivo oxygen...

This federal Project Grant award for $569,695.00, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), supports research into the therapeutic potential of phrenic proprioceptors, or sensory neurons, to restore respiratory function after cervical spinal cord injury. The research, conducted by Marquette University, aims to test the hypothesis that activating these phrenic proprioceptors can induce spinal plasticity and improve breathing...

This Project Grant award from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), provides $249,000.00 to Dr. Nicholas Burgraff to conduct research aimed at understanding the neurophysiological mechanisms by which opioids disrupt respiratory function and lead to airway constriction. The research seeks to identify new therapeutic approaches to mitigate the life-threatening respiratory complications of opioid overdose. The award will...

This Project Grant award from the National Science Foundation's Biological Sciences program provides $643,665 to the National Marine Mammal Foundation, Inc. to conduct collaborative research on oxygen transport mechanisms in elite diving mammals. The 4-year project, beginning December 1, 2023, will evaluate and model in vivo oxygen delivery during dive simulations with California sea lions and bottlenose dolphins. It will also elucidate the biochemical mechanisms regulating red blood cell oxygen...

This $123,349 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Rutgers, The State University of New Jersey to investigate the convergent mechanisms by which seizures and alcohol poisoning affect breathing. The key objectives are to determine how increases in adenosine signaling triggered by seizures and alcohol poisoning suppress...

This federal Project Grant award of $333,810 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop the RMT Complete, an all-in-one respiratory muscle training device and mobile application. The RMT Complete is designed to enhance breathing function and quality of life for patients with chronic obstructive pulmonary disease (COPD) by combining features such as an integrated manometer, wide resistance training...