Project Grant N629092012032

The Cold Spring Harbor Laboratory will provide a two-week intensive Synthetic Biology Summer Course from August 2022 through July 2025 under a $515,458 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences. The course aims to introduce scientists to synthetic biology through a combination of practical lectures, open-ended research projects, and seminars led by field experts. Participants will gain hands-on experience with techniques such as cell-free...

This $1,000,000 Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program supports research by the University of California, San Francisco (UCSF) to design, build, and test synthetic signaling systems built from computationally-designed de novo protein components. The goal is to develop stable, tunable, and modular signaling systems capable of precisely controlling biological processes, with applications in biotechnology such as engineered cells for...

This $240,000 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) funds a postdoctoral research fellowship to investigate the role of genome organization on de novo gene origination. The research aims to test a new theoretical model explaining the process of new gene evolution, by examining how the genome's structural features influence the birth of genes that arise from non-coding regions. The key components of the research include: 1)...

This National Science Foundation (NSF) Biological Sciences program award to the University of Texas at Austin provides $650,195 over 3 years to investigate regulatory mechanisms used by RNA-binding proteins within a bacterial central carbon metabolism network. The researchers will use experimental and computational tools to: (i) explore the formation of bacterial condensates as a post-transcriptional gene regulation mechanism, and (ii) elucidate dynamic regulatory outcomes from alternative usage...

This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $374,999 to the University of California, San Diego to conduct collaborative research on the biological mechanisms underlying analog information storage in chromatin state. The research aims to investigate how gene expression can be locked at a range of levels, rather than just binary "on" or "off" states, which could enable new applications in tissue...

This three-year, $992,280 Project Grant from the National Science Foundation's Biological Sciences program (CFDA 47.074) supports research into "Synthetic P-Bodies: Coupling Gene Expression and Ribonucleoprotein Granules in Synthetic Cell Vesicles for Sensing and Response" being conducted by The University of New Mexico from August 2021 through July 2024. The University will design and test genetic circuits, optimize lyophilization protocols, and develop cell-free protein expression...

This National Science Foundation (NSF) Project Grant award under the Biological Sciences program (CFDA 47.074) provides $429,656.00 to Cornell University to conduct research using synthetic biology methods to engineer microorganisms to produce valuable plant natural products. The key objectives are to reconstitute plant biosynthetic machinery in yeast in order to better understand and harness plant enzyme complexes for natural product synthesis. This research aims to develop a more resilient...

This $1,120,000 Project Grant award from the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074) aims to explore the boundaries of life's genetic alphabet beyond the natural 4-letter system (A, T, G, C). The research will develop model systems to study the biomolecular properties of a 6-letter genetic alphabet (A, T, G, C, P, Z) and map critical interactions necessary for translation of this expanded genetic code. The project will use synthetic biology and chemical...

The National Science Foundation awarded a $805,000 Project Grant to The Washington University for research titled "COLLABORATIVE RESEARCH: DESIGNING A MINIMIZED GENOME CYANOBACTERIAL CHASSIS FOR EFFICIENT BIOPRODUCTION." The period of performance for this award is from February 15, 2021 through January 31, 2024. The grant supports research under the Biological Sciences program (CFDA 47.074) to design a minimized genome cyanobacterial chassis for efficient bioproduction. Specifically,...

The National Institute of General Medical Sciences (NIGMS) has awarded a $389,653 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF-SUNY), doing business as Rf-SUNY At The University At Albany. This 5-year project, starting on January 1, 2025, aims to develop a transdisciplinary research program centered around AI-supported biosensing and precision therapeutics using DNA nanotechnology and...