Project Grant K99MH142727
- The National Institute of Mental Health awarded $1.579 million to the Research Foundation For Mental Hygiene, Inc., operating as the New York State Psychiatric Institute, on July 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to fund basic neuroscience research into the circuit mechanisms by which early-life adversity produces sustained reward deficits. The research examines how childhood trauma—including abuse, neglect, and chronic stress—alters neural circuits governing...
- The National Institute of Mental Health awarded Children's Research Institute $654,005 on June 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate the function of paralaminar amygdala neurons from adolescence to adulthood using a mouse model. The recipient will examine how paralaminar nucleus neuronal responses change over the adolescent-to-early-adulthood transition, determine the necessity and sufficiency of these neurons in that transition, and characterize...
- The National Institute of Neurological Disorders and Stroke awarded The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. $372,880 on July 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating lateral habenula circuit dysfunction in mild traumatic brain injury and its causal contribution to associated neuropsychiatric disorders including depression, anxiety, and...
- The National Institute of Mental Health awarded The Johns Hopkins University $384,245 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to develop DNA probes and modified extracellular vesicles as therapeutic tools to reverse stress-induced epigenetic changes in the brain. The project addresses the role of chronic stress and cortisol exposure in causing epigenetic modifications that disrupt genes critical for brain function and neurodevelopment, contributing to...
- The National Institute of Mental Health awarded The Washington University $103,310 on August 3, 2026, under the Mental Health Research Grants program (CFDA 93.242, K99MH144521) to investigate the causal dynamics of human amygdala-prefrontal circuits during fear extinction learning. The recipient will conduct intracranial electrophysiology and neuromodulation research using clinically indicated stereoelectroencephalography electrodes implanted in epilepsy patients undergoing SEEG monitoring....
- The National Institute of Mental Health awarded New York University $1.694 million on June 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct bioinformatic and experimental research on long non-coding RNAs (lncRNAs) in stress response and psychiatric disorder resilience. The research integrates genetic, transcriptional, and epigenetic datasets to identify lncRNAs mediating stress susceptibility and resilience in the brain. The project involves two primary aims:...
- The National Institute of Mental Health awarded Northeastern University $157,500 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to explore the role of microglia in developmental effects of early life adversity on prefrontal cortex glutamate receptor development. The research investigates how microglia, resident immune cells of the brain, drive changes in NMDA receptor expression in adolescents exposed to early life adversity such as maternal separation. Prior...
- The National Institute of Mental Health awarded The Leland Stanford Junior University $426,991 under the Mental Health Research Grants program (CFDA 93.242) on August 3, 2026, to support research decoding medial prefrontal cortex (MPFC) plasticity across developmental life stages. The recipient is investigating critical periods of synaptic plasticity in the MPFC using high-throughput assays measuring long-term potentiation in mouse brain slices via multielectrode recording arrays. Aim 1 maps...
- The National Institute of Mental Health awarded Massachusetts Institute of Technology $127,224 under the Mental Health Research Grants program (CFDA 93.242) on August 1, 2026, to investigate neural mechanisms governing sensory-driven decision making through study of amygdala-striatal pathways. The K99 award (K99MH141244) funds research into how basolateral amygdala neurons projecting to the tail of the striatum instruct the selection of instrumental actions during perceptual decision making. The...
- The U.S. Department of Defense's Military Medical Research and Development program (CFDA 12.420) has awarded a $5,596,529 project grant to the Icahn School of Medicine at Mount Sinai to conduct research on understanding the interactions between gene X and stress across different brain cell types in post-traumatic stress disorder (PTSD). This 4-year grant, awarded on Sep 30, 2023, will fund studies to establish a human induced pluripotent stem cell-based platform for testing the functional impact...
The National Institute of Mental Health awarded Lieber Institute Inc. $114,200 on August 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support translational research on stress susceptibility in amygdala-prefrontal circuits underlying post-traumatic stress disorder (PTSD). The research investigates how traumatic stress impairs cellular and molecular function in neural circuits critical to fear regulation and extinction learning, with the objective of identifying analogous cell types and mechanisms in human brain tissue that could inform novel therapeutics targeting PTSD's resistance to cognitive-behavioral exposure therapy. The recipient, Lieber Institute for Brain Development, a Baltimore-based nonprofit research organization, conducts human postmortem brain tissue procurement and spatial genomics analysis across the National Institute of Mental Health's research portfolio. The award is a K99 Pathway to Independence grant made for a two-year period with no renewal option, running through July 31, 2028, with place of performance in Baltimore, Maryland.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $114.2k | 8/3/26 |