Project Grant K99GM166795
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services, awarded $440,465 to the Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of genome folding and function. Over the five-year performance period ending February 28, 2031, the award funds research into chromosome architecture and the mechanisms that shape it—motor-driven loop...
- This $868,584 Project Grant, awarded September 1, 2025, by the National Institute of General Medical Sciences through its Biomedical Research and Research Training program (CFDA 93.859), supports fundamental research investigating how ribonucleic acid (RNA) modifications regulate adaptive messenger RNA (mRNA) translation. The University of Texas Health Science Center at Houston will conduct a two-year research initiative (through August 31, 2027) focused on elucidating the roles of TRMT1L, a...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $460,625 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop machine learning methods that model cis- and trans-regulatory drivers of chromatin accessibility from single-cell multiomic datasets. Over the five-year period of performance through May 31, 2031, the recipient will create machine learning approaches that simultaneously account...
- The National Institute of General Medical Sciences awarded Brown University $583,770 on July 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of translational control and gene regulation. The recipient will conduct five years of fundamental research on how ribosomes, mRNAs, and nascent polypeptide chains interact to regulate protein synthesis efficiency and gene expression. The work builds on eleven years of prior investigation into...
- The National Institute of General Medical Sciences awarded Worcester Polytechnic Institute $431,535 on August 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop and validate integrative machine learning methods for characterizing alternatively spliced isoforms of RNA-binding proteins and their functional roles in gene expression, RNA metabolism, and cellular homeostasis. The project will combine transcriptomic, proteomic, interactomic, and structural...
- The National Institute of General Medical Sciences awarded The Regents of the University of California, doing business as University of California, Berkeley, $425,364 on August 17, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate unconventional gene regulatory mechanisms in meiosis and related cellular differentiation processes. The research focuses on how cells coordinate simultaneous activation and repression of distinct gene clusters during...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $433,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop network-based computational models for understanding continuous cell states in human development and disease. Over five years through February 28, 2031, the research group will create methods to integrate multiple modalities of large-scale genomics data, with emphasis on epigenetics and the...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $899,250 on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to develop new computational-experimental approaches for measuring and modeling gene expression trajectories at the single-cell level. The research integrates experimental systems biology and genomics with machine learning and data science to track RNA production, processing, and degradation rates....
- The National Institute of General Medical Sciences, operating as part of the Department of Health and Human Services National Institutes of Health, awarded the University of Utah $423,500 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859). The award funds research investigating the biological functions, biosynthesis, and dynamic regulations of RNA chemical modifications. The research program addresses three key challenges: identifying proteins that...
- The National Institute of General Medical Sciences awarded Northwestern University $440,000 on April 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the role of mRNA internal 2-O methylation in post-transcriptional regulation. The research combines nanopore direct RNA sequencing and machine learning methods to characterize how 2-O methylation (NM) governs mRNA function and metabolism. Three complementary projects are proposed: the first...
The National Institute of General Medical Sciences awarded Whitehead Institute for Biomedical Research $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate cell type-specific regulatory mechanisms in untranslated regions of messenger RNAs and develop machine learning models for predicting the functional impact of genetic variants across different cellular contexts. The research probes untranslated region (UTR) activity across three physiologically relevant cell types—stem cells, neurons, and cardiomyocytes—to elucidate how identical sequences produce distinct regulatory effects in different cell types. The three project aims include investigation of mechanisms underlying the most biologically significant UTRs; systematic mapping of RNA-binding proteins associated with the top 100 UTRs to identify molecular determinants of UTR-mediated cell type specificity; and development of a machine learning model that predicts functional impact of genetic variants in UTRs across cell types with applications for forecasting UTR activity. The award funds research at Whitehead Institute's Cambridge, Massachusetts location. The period of performance runs from September 1, 2026, through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/20/26 |