Project Grant K99DC024024
- The National Institute on Deafness and Other Communication Disorders awarded Northeast Ohio Medical University $631,040 on February 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate the role of metabotropic glutamate receptor 5 (MGLUR5) in the development of auditory brainstem sound localization circuits in mice. The research will examine the anatomy, physiology, and loss-of-function consequences of MGLUR5 during development and...
- The National Institute on Deafness and Other Communication Disorders awarded The Ohio State University $664,740 on August 15, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate neural encoding and auditory perception in cochlear implant users. The research addresses two unresolved issues in cochlear implantation: substantial variation in clinical outcomes among implant users and widespread difficulty understanding speech in complex...
- The National Institute on Deafness and Other Communication Disorders awarded Northeast Ohio Medical University (Neomed) $440,000 on July 20, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to develop genetically modified Mongolian gerbil strains for auditory neuroscience research. The project will create new gerbil lines with targeted fluorophore or recombinase expression in specific neuron types of the lateral superior olive, a brainstem region...
- The National Institute on Deafness and Other Communication Disorders awarded New York University $279,234 on May 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds research into neural circuits supporting olfactory computation and perception, combining two-photon calcium imaging with fast GCaMP8 indicators, patterned optogenetics, and large-scale silicon probe recordings to study olfactory dynamics in awake mice. The K99/R00...
- The National Institute on Deafness and Other Communication Disorders awarded New York University $134,109 on December 19, 2025, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The funded research investigates plasticity and social neuromodulation of developing auditory cortical circuits in postnatal mice. The K99 phase employs longitudinal tracking of auditory cortex neurons from the onset of hearing throughout development to examine how external...
- The National Institute on Deafness and Other Communication Disorders awarded the University of Pittsburgh $664,448 on September 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds investigation of how heterogeneous neural responses in auditory cortex and secondary motor cortex contribute to auditory learning and perception. The project combines large-scale neural recordings with optogenetic manipulations to examine how local auditory...
- The National Institute on Deafness and Other Communication Disorders awarded Oregon Health & Science University $645,488 on July 27, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to characterize how the auditory cortex processes speech and natural sounds in noisy, dynamic acoustic environments. The research addresses the clinical problem that listeners with hearing loss struggle to understand speech in complex noise despite hearing aids and...
- The National Institute on Deafness and Other Communication Disorders awarded The Johns Hopkins University $194,270 on May 11, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) to investigate the development of auditory thalamocortical circuits and how they are altered in cases of congenital deafness. The project will establish a foundational understanding of how the thalamus and auditory cortex develop and mature through sensory experience, with...
- The National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health, awarded The Washington University $557,999 on September 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds investigation of how inner hair cells in the cochlea encode sound frequency and intensity across a wide dynamic range. The research employs in vivo two-photon cochlear imaging integrated with single-cell...
- The National Institute on Deafness and Other Communication Disorders awarded New York University $381,376 on September 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds experimental and computational investigation of synaptic plasticity rules engaged in auditory cortex development and learning. The research generates datasets on fundamental plasticity processes during critical developmental periods, comparing spike-timing-dependent...
The National Institute on Deafness and Other Communication Disorders awarded Northeast Ohio Medical University $132,486 on August 1, 2026, under the Research Related to Deafness and Communication Disorders program (CFDA 93.173). The award funds investigation of inhibitory nuclei within the trapezoid body and their roles in sound localization, addressing deficits in spatial hearing that commonly accompany age-related hearing loss and neurodevelopmental disorders. The project integrates computational modeling of spiking neural networks, in vivo optogenetic manipulation, auditory brainstem response measurement, and behavioral assessment in Mongolian gerbils to characterize how the ventral trapezoid body's feedforward inhibition contributes to spatial acuity during rapid sound sequences and to link nucleus-specific activity to clinically measurable biomarkers. The work runs through July 31, 2028, with performance at Rootstown, Ohio. The award is structured as a K99/R00 career development grant, with the K99 phase extending computational models of the auditory brainstem to include ventral trapezoid body inhibition and testing model predictions through optogenetic manipulation and extracellular recording. The R00 phase will connect nucleus-specific activity to auditory brainstem response and binaural interaction components as clinical markers and evaluate perceptual consequences of targeted inhibition across the three trapezoid body nuclei.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.5k | 7/20/26 |