Project Grant K99AG100987
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $452,375 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) effective January 1, 2026, through December 31, 2027, under the Aging Research program (CFDA 93.866). This award supports basic biomedical research investigating the mechanisms underlying Lewy Body Dementia (LBD), specifically examining how mutations in the GBA1 gene—which encodes the lysosomal enzyme...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $790,288 Project Grant on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct genetic research on the 17q21.31 MAPT locus and its relationship to neurodegenerative diseases. The research will be performed in San Francisco, California, with an ultimate completion date of November 30, 2030. The project delivers advanced scientific research services focused on...
- Federal Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $3.64 million Project Grant to The Trustees of Columbia University in the City of New York on August 5, 2025, for research extending through July 31, 2030. The FUNGEN-XQTL project will generate comprehensive multi-ancestry molecular quantitative trait loci (xQTL) data and advanced computational analysis to identify causal genes, cell types, and molecular mechanisms...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $1,459,072 on August 1, 2025, under the Aging Research program (CFDA 93.866) to conduct research on Alzheimer's Disease (AD)-related neurological dysfunction. The research will deliver scientific knowledge and methodological innovations focused on understanding how inhibitory interneurons—specifically parvalbumin (PVALB) and somatostatin (SST) cell types—contribute...
- Federal Grant Award Summary Award Details: The National Institute on Aging (NIA) awarded a Project Grant totaling $454,937 to The Research Foundation For The State University Of New York, operating as Stony Brook University, under the Aging Research program (CFDA 93.866). The award was issued on February 15, 2026, with a project completion date of January 31, 2028. Research Scope: This project, titled "Regulatory Landscape of Neurodegeneration by Single-Cell Spatial Multiomics,"...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Michigan a $303,449 project grant effective June 1, 2025, through May 31, 2027, under the Aging Research program (CFDA 93.866) to investigate the genomic impact of transposable elements (TEs) in Alzheimer's disease and related dementias (ADRD). The research will leverage large-scale genomic datasets and clinical information from major Alzheimer's disease cohorts to overcome analytical challenges...
- Federal Grant Award Summary The National Institute on Aging awarded a $1.28 million Project Grant under the Aging Research program (CFDA 93.866) to the University of Arizona, effective August 1, 2025, through May 31, 2030. The award funds research investigating the relationship between liquid-liquid phase separation (LLPS) of transactive response DNA binding protein of 43 kDa (TDP-43) and mitochondrial dysfunction in neurodegeneration. TDP-43 mutations are associated with amyotrophic lateral...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,750 Project Grant to the San Diego Biomedical Research Institute on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853), with a completion date of April 30, 2028. The grant funds research to discover noncanonical autophagy modulators for Alzheimer's disease and related dementias, including frontotemporal degeneration...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $310,083 to the University of Arizona under the Aging Research program (CFDA 93.866) for a two-year project period from September 1, 2025, through August 31, 2027. This Project Grant supports biomedical research investigating the role of TMEM106B (Transmembrane Protein 106B) and mitochondrial dysfunction in frontotemporal lobar degeneration (FTLD) and other age-related dementias. The research aims to elucidate...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $162,000 Project Grant to Washington University's Office of Sponsored Research Services, effective March 1, 2026 through February 28, 2029, under the Aging Research program (CFDA 93.866). This research initiative focuses on identifying and characterizing new therapeutic targets in TDP-43 (TAR DNA-binding protein 43) proteinopathies—a class of neurodegenerative diseases characterized by aberrant nuclear clearance and...
The National Institute on Aging (NIA) awarded a $123,066 Project Grant to Translational Genomics Research Institute (TGen Research Institute) under the Aging Research program (CFDA 93.866) on July 1, 2026, with a completion date of April 30, 2028. The award funds research to identify key molecular differences between Lewy Body Disease (LBD) and Alzheimer's Disease (AD) through multi-omics analysis. TGen will deliver transcriptomic and genomic characterization services of postmortem anterior cingulate cortex tissue samples from 607 neuropathologically defined cases, utilizing bulk short-read and long-read RNA sequencing, single-nucleus RNA sequencing, and integration of single nucleotide polymorphism (SNP) array and bulk RNA sequencing data to identify expression quantitative trait loci (eQTLs) and splice QTLs (sQTLs). The research addresses the clinical challenge of distinguishing between overlapping neurodegenerative pathologies that present with similar symptoms and frequently co-occur. By incorporating sex as a biological variable and examining isoform dysregulation, cell-type-specific transcriptional changes, and genomic variants linked to dysregulated gene expression across disease pathologies, the project aims to close knowledge gaps regarding molecular alterations that differentiate LBD from AD. These findings are intended to inform targeted treatment strategies and improve diagnostic accuracy for dementia disorders affecting nearly 7 million Americans.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.1k | 7/1/26 |