Project Grant K43TW013130
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $897,448 to The Johns Hopkins University to conduct research on the causality of post-tuberculosis (TB) lung disease in rural Uganda. The study aims to evaluate lung function and respiratory symptoms both before and after TB diagnosis to better understand how much post-TB sequelae reflect the TB disease...
- This federal Project Grant award of $709,902 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to establish a well-characterized cohort of individuals with post-tuberculosis lung disease (PTLD) in Uganda. The key objectives are to determine whether sex, HIV serostatus, and air pollution exposure are associated with distinct lung function and chest imaging phenotypes of PTLD. The award will support the enrollment of 650 post-TB and 165 non-TB...
- This $854,000 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), aims to assess post-tuberculosis (TB) lung disease in TB patients with and without HIV coinfection. The project will utilize novel positron emission tomography (PET) imaging techniques, such as 11C-rifampin PET, to longitudinally profile lesional characteristics and antibiotic exposures in animal models...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,136,143 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to study post-tuberculosis lung disease (PTLD) in youth with and without HIV globally. The project will leverage the Tuberculosis Sentinel Research Network (TB-SRN) in 11 countries to establish the prevalence of PTLD in youth, identify modifiable risk factors, and assess the impact on quality of life....
- This $830,261 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research program) supports research on post-tuberculosis (TB) lung disease among individuals successfully treated for TB in Lima, Peru. The project, titled "Host- and Pathogen-Specific Risk Factors for Post-Tuberculosis Lung Disease among People Successfully Treated for TB in Lima, Peru: BEAT-PTLD," will evaluate 1,000 TB patients and 291 community...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) is supporting a research project titled "Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease". The $187,461 award will be used to 1) define the clinical patterns of post-tuberculosis lung disease (PTLD) and associated outcomes to identify those most in need of pulmonary rehabilitation (PR); 2) develop a structured process for...
- This Project Grant award of $3,145,850.00 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The award supports research at The Johns Hopkins University to investigate macrophage senescence as a driver of granuloma failure and necrosis in pulmonary tuberculosis (TB) and TB/HIV coinfection. Key objectives include understanding the role of stress-induced senescence in myeloid...
- This $190,892 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will support a study to optimize tuberculosis (TB) active case finding strategies in Nairobi, Kenya. The key products and services to be delivered include: Employing multiple data sources on human mobility and activity spaces to identify high-yield geographic locations for TB screening within Nairobi. Developing a geospatial model to estimate...
- This $489,500 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support the establishment of a new in vitro lung alveolar epithelial cell organoid model derived from human bronchoalveolar lavage fluid (BALF). The goal is to develop a physiologically relevant model for studying the human innate immune response to Mycobacterium tuberculosis (MTB) infection and evaluate the effects...
- This federal Project Grant award of $639,474, provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports a study to investigate the impact of maternal mental health interventions on child respiratory health. The study aims to leverage an ongoing birth cohort in rural Pakistan to generate evidence on how childhood adversity, such as poverty and maternal depression, affects respiratory function and symptoms in early...
This $136,718 Project Grant award from the National Institutes of Health's Fogarty International Center (CFDA 93.989 - International Research and Research Training) supports a study to investigate the long-term respiratory health impacts of pulmonary tuberculosis in children and adolescents in The Gambia. The project, led by Principal Investigator Dr. Esin Nkereuwem from the Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, aims to: 1) characterize respiratory health trajectories in pediatric TB survivors using longitudinal data analysis; 2) identify predictors of long-term respiratory impairment to develop a risk stratification model; and 3) refine and validate an AI-powered tool for detecting and monitoring post-TB lung disease. The award period runs from September 16, 2025 to August 31, 2030, and the project will leverage the established research infrastructure and participant cohorts at the Medical Research Council Unit in The Gambia.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $136.7k | 9/14/25 |