Project Grant K43TW013094
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $136,050 to Tufts University School of Medicine to conduct research on the mechanisms that control Clostridioides difficile spore germination. The research aims to understand how C. difficile, which lacks traditional germinant receptors found in other spore-forming bacteria, uses two pseudoprotease enzymes, CspA and...
- This Project Grant award of $2,872,722 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the role of penicillin-binding proteins (PBPs) in the Clostridioides difficile life cycle and develop new PBP inhibitors to target C. difficile sporulation. The research aims to enhance the understanding of PBPs across bacterial species and provide new insights into the unique...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $136,104 Project Grant to Tufts University School of Medicine. The grant, awarded on October 24, 2025, will support research to investigate the effect of Clostridioides difficile's (C. difficile) spatial distribution and toxin gene expression within the colon on disease severity. The research will utilize fluorescent reporter strains...
- This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $261,492 to Tufts University School of Medicine to study the epigenetic regulation of sporulation in Clostridioides difficile, a major nosocomial pathogen. The research aims to elucidate the role of the C. difficile-specific DNA methyltransferase CamA in mediating the epigenetic regulation of spore formation, which...
- This is a $300,892 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The grant supports research by the University of North Carolina at Chapel Hill to identify and annotate Rho, NusA, and NusG dependent transcriptional terminators in Clostridioides difficile. The objective is to determine how these factors regulate the expression of key virulence genes involved in C. difficile...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $161,859 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Texas A&M University System Health Science Center (TAMU HSC) to conduct research on discovering novel antivirulence drug targets for Clostridioides difficile infection (CDI). The research aims to identify genetic mechanisms that regulate the production of virulence toxins by C. difficile, with the goal of finding...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund research to characterize the molecular mechanisms and evolution of cyclic diguanylic acid (c-di-GMP) signaling in the antibiotic-producing bacterial genus Streptomyces. The $383,746 award, with a performance period from January 1, 2025 to December 31, 2029, will be executed by Cornell University's Office of Sponsored...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) is supporting research to develop a novel, water-soluble, cationic bolaamphiphile (CAB) platform nanocarrier complexed with an antisense oligonucleotide (ASO) targeting the essential C. difficile dnaE gene. The $426,875 award, which began on Jul 14, 2025 and runs through Jun 30, 2027, aims to advance this platform technology as a...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $111,513 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to President and Fellows of Harvard College, doing business as Harvard Medical School, on January 18, 2025. The grant supports research to investigate how gram-positive bacteria use the nucleotide second messenger cyclic-di-AMP to monitor and respond to defects in the cell envelope. The research aims to understand the...
- This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
This Project Grant award, valued at $151,200.00, was issued by the Fogarty International Center (FIC) under the International Research and Research Training program (CFDA 93.989) to Mahidol University in Thailand. The award, which runs from September 16, 2025 to August 31, 2030, supports research to characterize the cyclic-di-AMP (c-di-AMP) pathway in the bacterium Clostridioides difficile. The research aims to explore the c-di-AMP pathway as a novel drug target for C. difficile, which is a leading cause of antibiotic-resistant hospital-acquired infections. Key objectives include elucidating the structures and functions of c-di-AMP receptors in C. difficile and identifying small molecules that target these proteins. The findings from this project are expected to contribute to the development of new therapeutic approaches for addressing the global challenge of antimicrobial resistance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $151.2k | 9/14/25 |