This Project Grant award of $789,442 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research on placental malaria and immunity in pregnant women. The primary objectives are to: 1) Determine how malaria and gravidity impact the circulating and placental blood myeloid compartment in pregnancy using single cell proteomic and transcriptomic approaches; 2) Assess how Plasmodium falciparum...
This federal Project Grant award of $791,864 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify molecular factors controlling chromatin organization and gene regulation in the malaria parasite Plasmodium falciparum. The research aims to elucidate the importance of long non-coding RNAs (lncRNAs) in parasite development, virulence, and sexual differentiation, with the goal...
This $153,056 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to The Washington University will support research to investigate heme homeostasis mechanisms in the malaria parasite Plasmodium falciparum. The research aims to identify parasite heme-binding proteins and assess their essentiality for parasite viability, as well as investigate the role of the heme detoxification protein PfHDP in parasite...
This $1,480,500 federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) will fund research by The Trustees of Columbia University in the City of New York to identify and characterize the roles of non-coding RNAs in regulating drug-induced quiescence in Plasmodium falciparum, the parasite that causes malaria. The project aims to uncover novel epigenetic and epitranscriptomic mechanisms that enable...
This Project Grant award of $375,000.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) supports a research project to investigate the role of messenger ribonucleoprotein (mRNP) granules in regulating RNA metabolism and translation in the malaria parasite Plasmodium falciparum. The project aims to identify molecular markers for distinct mRNP types, determine their protein and mRNA compositions, and characterize their...
This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
This federal Project Grant award of $756,077, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a 5-year research study on the long-term immunologic, cardiovascular, metabolic, and neurocognitive consequences of inflammation in children with perinatal HIV in sub-Saharan Africa. The primary objectives are to assess the durability of inflammation and immune...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $479,204 to the University of Maryland, Baltimore to conduct research on parasite variant surface antigens and their role in severe malaria. The research aims to identify parasite genes associated with severe disease, which could inform vaccine and drug development. Key aspects include: Sequencing variant surface antigen transcripts...
The Project Grant award R01AI187153 was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on identifying genetic factors associated with sexual stage development (gametocyte formation) in the malaria parasite Plasmodium falciparum. The $700,288 award, with a project period from Nov 2024 to Oct 2029, will fund a research project at the University of South Florida to perform...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $108,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Kenyatta National Hospital (KNH) in Kenya. The purpose of this 2-year grant, with an award date of August 1, 2024 and a completion date of January 31, 2026, is to strengthen KNH's pre-award grants management capacity. The key products and services to be delivered through this funding include: 1) Training two senior research...
This federal Project Grant award from the National Institutes of Health's John E. Fogarty International Center (CFDA 93.989 - International Research and Research Training) provides $111,024 to Mount Kenya University in Kenya to investigate the molecular and cellular mechanisms underlying placental malaria. The award aims to leverage the university's placental biobank to identify transcriptomic signatures associated with placental malaria and detect these signatures in maternal circulation through analysis of placental extracellular vesicles and cell-free RNA. This research seeks to uncover processes and factors that can be targeted to prevent or mitigate the adverse impacts of placental malaria, which poses significant threats to maternal and child health in sub-Saharan Africa. The 5-year project period runs from September 1, 2024 to August 31, 2029.