This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,304,338 to Wake Forest University Health Sciences to conduct a trans-omics analysis of African American deceased donor kidneys to optimize kidney transplant outcomes. The primary goals are to: 1) Identify APOL1 gene expression profiles in donor kidneys and factors modifying effects...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $148,880.00 to the University of Mississippi Medical Center to investigate the long-term effects of preeclampsia (PE) on offspring. The key research objectives are to: 1) Test the hypothesis that B cells from PE women produce autoantibodies that contribute to hypertension,...
This $550,000 Project Grant award from the National Science Foundation (NSF) under the Technology, Innovation, and Partnerships (CFDA 47.084) program supports the development and validation of a non-invasive, multiplex blood test for the early detection of preeclampsia, a serious pregnancy complication. The project aims to advance the detection of vascular dysfunction, particularly preeclampsia, by optimizing a blood test that targets disease-inducing signaling proteins on the surface of...
The National Heart, Lung, and Blood Institute (NHLBI) has awarded a $648,073 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to The Johns Hopkins University to conduct the ADHINCRA study, which aims to address hypertension care in Ghana and Nigeria. The project will implement a multilevel intervention that integrates home-based blood pressure monitoring, team-based care with nurse training, and simplified hypertension treatment protocols to improve blood pressure control in...
This $223,176 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the impact of APOL1 copy number variations (CNVs) on kidney disease susceptibility in African Americans. The award recipient, Beth Israel Deaconess Medical Center (BIDMC), will develop computational approaches to characterize the risk variant architecture of APOL1 CNVs and determine the...
This Project Grant award, ID R21HG013814, was provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research Federal Grant Program (CFDA 93.172) to Case Western Reserve University. The $874,886 award, effective from September 9, 2024 to July 31, 2025, aims to quantify and identify environmental modifiers of genetic associations related to kidney outcomes, using the APOL1 genetic model. The proposed research will leverage large, diverse datasets such as the UK...
This $232,500 Project Grant awarded by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to Wake Forest University Health Sciences will fund research to establish the neuroprotective actions of the apelinergic axis on the long-term cerebrovascular consequences of preeclampsia. The research aims to improve understanding of the protective role of the apelin/APJ axis in preeclampsia, a hypertensive disorder of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $869,696 to Vanderbilt University Medical Center to investigate the relationship between preeclampsia during pregnancy and the development of heart failure with preserved ejection fraction (HFpEF) in women. The key objectives are to: 1) measure the relationship between post-partum subclinical left ventricular diastolic dysfunction and...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $133,500 Project Grant (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to Boston Medical Center Corporation (BMC) with a start date of September 1, 2024 and end date of August 31, 2026. The grant will fund research on the relationship between APOL1 genotypes and biomarkers of immune activation and tubular injury in the context of chronic kidney disease (CKD) in sub-Saharan...
This $2,559,308 Project Grant was awarded on January 14, 2025 by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports a study examining the impact of severe pre-eclampsia on heart function in a racially diverse cohort of women during and after pregnancy. The study aims to characterize the cardiomyopathic genetic profile of participants and assess the functional impact of specific genetic...