Project Grant K23NS140493

The National Institute of Neurological Disorders and Stroke awarded the Hugo W. Moser Research Institute at Kennedy Krieger, Inc. $234,360 on September 5, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to identify phenotypic subtypes and disease trajectories in adrenomyeloneuropathy using quantitative sensorimotor measures and spinal cord MRI indices.

The research addresses the lack of sensitive outcome measures and biomarkers that have limited clinical trial success in AMN, the most common form of X-linked adrenoleukodystrophy. The project will obtain cross-sectional sensorimotor outcome measures in 80 individuals with AMN using machine learning cluster analysis to determine distinct phenotypic subtypes and correlate them with spinal cord MRI abnormalities in the dorsal columns and lateral corticospinal tracts. The work will also determine whether longitudinal sensorimotor measures and spinal cord MRI indices change over a two-year period to validate quantitative assessments of AMN progression.

Performance occurs in Baltimore, Maryland. The period of performance extends from the award date through August 31, 2031. This is a Project Grant, a category of assistance funding under the NINDS extramural research program supporting investigator-initiated research in neuroscience and neurological disorders.