Screening strategies for sexually transmitted infections in a high HIV incidence setting in south africa

Ended Project Grant Awarded Last action

Award ID
K23AI174917
Recipient
Awarding agency
Obligated
$770,465

Award facts

Assistance listing
93.855 Allergy and Infectious Diseases Research
Completion date
Place of performance
Massachusetts, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
Curable sexually transmitted infections (STIS) are highly prevalent among adolescents and young adults in sub-saharan africa, who are also at the highest risk of acquiring HIV. Untreated STIS, such as gonorrhea, chlamydia, and trichomoniasis, increase HIV acquisition and transmission risks and can lead to significant morbidity for women, including pelvic inflammatory disease, tubal infertility, and pregnancy complications. Faced by constraints in diagnostic capacity, many countries rely on syndromic management, which has poor sensitivity and specificity, particularly because the majority of curable STIS are asymptomatic. As accurate diagnostic tests for STIS are developed, effective screening strategies to reach populations at high risk for STIS and HIV, such as adolescents and young adults in rural south africa, need to be rigorously evaluated to inform the future implementation of STI screening programs. I am an infectious disease physician with a background in clinical epidemiology and an interest in decreasing the burden of STIS and their contribution to HIV transmission in sub-saharan africa. I am motivated to pursue training to apply new methods to the design and evaluation of STI screening strategies in rural south africa. The NIH K23 mentored research career development award will afford me the opportunity to gain the necessary skills to become an independent clinician investigator. I will pursue training in (1) qualitative research methods, (2) discrete choice analysis and clinical trial design, and (3) implementation science methods and frameworks. I have designed a didactic curriculum to address each of these training aims and assembled a multidisciplinary mentorship team. My primary mentor is DR. Ingrid bassett, an expert in cohort studies and implementation research to evaluate HIV and tuberculosis linkage to care in south africa. My mentorship team additionally includes experts in community-based, peer-led interventions for sexual health and HIV prevention in south africa (DR. Maryam shahmanesh), qualitative research (DR. Christina psaros), and biostatistics (DR. Robert parker). With their guidance, I will assess young people's preferences for STI screening and design and evaluate a community- based STI screening strategy in rural south africa through the following specific aims: 1) evaluate motivation and preferences for STI screening among adolescents and young adults using qualitative methods, 2) conduct a discrete choice experiment to quantify young people's preferences for community-based STI screening, and 3) evaluate the implementation of a new community-based STI screening strategy among adolescents and young adults. I will deepen an existing collaboration with the africa health research institute (AHRI), leveraging the infrastructure of a funded clinical trial. The proposed training and research aims will inform future efforts to expand STI screening in south africa, and will provide a strong foundation for my career as an independent clinician investigator focused at the intersection of STIS and HIV prevention.

Transactions

Action Obligated Date
Amendment $0
Amendment Screening strategies for sexually transmitted infections among young adults $0
Amendment $0
Amendment $0
Amendment $0
Amendment $35,703
Amendment $35,703
Amendment $152,925
Amendment $152,925
Amendment $0
Amendment $0
Amendment $195,569
Original award $197,640
Show all 13

Subawards

Subrecipient Amount Awarded
Africa Health Research Institute NPC The Africa Health Research Institute (AHRI) will assist with the staffing and conduct of study procedures for the proposed work, which aims to evaluate… $33,439

Quick answers

Who received award K23AI174917?

K23AI174917 was awarded to The General Hospital Corporation by National Institute of Allergy and Infectious Diseases (National Institutes of Health) on September 1, 2023.

How much is award K23AI174917 worth?

$770,465 has been obligated on K23AI174917.

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