Project Grant K22NS102881

Summary: Mechanisms of Misfolded Protein Sequestration and Degradation Marquette University received a $569,258 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective May 22, 2026, with a completion date of April 30, 2029. The award funds fundamental research to elucidate cellular mechanisms that sort, sequester, and degrade misfolded proteins into membrane-less compartments, with...

This Project Grant award of $350,275 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research investigating cell mechanobiology at the University of New Mexico Health Sciences Center. The research, spanning from July 1, 2025, through June 30, 2030, focuses on elucidating the molecular mechanisms by which extracellular glucose levels regulate cell mechanics and function across...

This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $378,750.00 to Saint Louis University to conduct research on YCX1, a newly discovered protein involved in calcium signaling. The project aims to: Characterize the biochemical activity and regulation of YCX1, a putative calcium/cation exchanger, and its role in calcium signaling within the endoplasmic reticulum and Golgi....

Federal Project Grant Award Summary Yale University received a $605,140 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective June 1, 2026, through March 31, 2030. The award funds fundamental research to elucidate cellular and molecular mechanisms of lipid-mediated trafficking pathways through the mammalian Golgi complex, a critical organelle responsible for protein sorting,...

The National Institute of General Medical Sciences (NIGMS) awarded a $371,250 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to Southern Illinois University Carbondale (SIU) to conduct research on the structural and dynamic properties of G-quadruplex (G4) nucleic acid motifs and their interactions with regulatory proteins. The project aims to use advanced two-dimensional infrared (2D IR) spectroscopy techniques, along with site-specific labeling, to probe...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is providing $426,938 to Virginia Commonwealth University to explore the role of a novel glutamate-driven signaling pathway initiated in maturing oligodendrocytes through the glutamate transporter GLT-1/EAAT2. This research aims to characterize the mechanisms downstream of...

The Regents of the University of California, Berkeley has been awarded a $632,806 Project Grant from the National Science Foundation's (NSF) Biological Sciences (CFDA 47.074) program to conduct research on the diversification of retinal ganglion cells in the zebrafish neural retina. This 5-year project will use single-nucleus RNA sequencing, genome engineering, and live imaging techniques to map the transcriptional landscapes and lineage relationships among the approximately 35-50 distinct types...

This Project Grant award from the National Center for Advancing Translational Sciences (NCATS) under CFDA 93.350 will provide $463,150 to The Regents of the University of California, San Francisco (UCSF) to establish proof-of-concept for enzyme replacement therapy (ERT) as a lifesaving treatment for sphingosine phosphate lyase insufficiency syndrome (SPLIS), an ultra-rare and often lethal metabolic disorder. The project aims to demonstrate the efficacy of ERT in preserving kidney function and...

This $151,000 Project Grant, awarded on August 4, 2025, by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports transdisciplinary research focused on developing proteolysis targeting chimeras (PROTACs) for degrading poly(ADP-ribose) polymerase-1 (PARP-1) in diseased human cells. The research addresses limitations of existing PARP-1 inhibitors by designing a novel class of protein degraders based on...

Federal Project Grant Award Summary The Salk Institute for Biological Studies received a $515,625 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded June 12, 2026, with completion targeted for March 31, 2031. This fundamental basic science research project investigates cytoskeletal connector proteins and their roles in cellular transport mechanisms. The research focuses on two primary...