Project Grant K22AI179938
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $639,084 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research to elucidate the functional heterogeneity of naive CD8 T cells, the precursors of effector and memory T cells that are critical for immune responses against pathogens and cancer. The 5-year project aims to provide a deeper understanding of...
- This $162,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to investigate the mechanisms that maintain the longevity and functional diversity of memory CD8+ T cells in both circulating and tissue-resident populations. The research aims to elucidate how these memory T cell subsets are regulated by cytokines during homeostasis and in response to...
- This $832,910 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify immune factors associated with risk of cytomegalovirus (CMV) disease in orthotopic liver transplant recipients. The University of Washington is the primary awardee, with the goal of developing a clinically useful measure of CMV disease risk to guide prevention efforts. The research focuses on...
- The National Institute of Allergy and Infectious Diseases (NIAID), through its Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $1,135,986 Project Grant to Northwestern University. The grant, effective January 1, 2025, aims to identify cellular and molecular targets for developing tissue/cell-specific strategies to prevent cytomegalovirus (CMV) reactivation and improve outcomes in kidney transplant recipients. The research will investigate the role of...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program (93.855), will support research to investigate the differences in immune responses between infants with congenital cytomegalovirus (cCMV) infection and those with postnatal CMV infection. The $598,664 award, with a performance period from May 2, 2025 to April 30, 2029, will enable the Research Institute at Nationwide Children's...
- The University of Pittsburgh received a $679,937 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to conduct research on mechanisms and therapeutic targeting of T cell regulation in heart allograft recipient monkeys. The 5-year project aims to investigate the impact of cytokine modulation and administration of novel, donor-specific chimeric antigen receptor regulatory T cells (CARTREG) on promoting long-term...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $682,879 to The Medical College of Wisconsin, Inc. to conduct research on the impacts of human cytomegalovirus (HCMV) infection on human neural tissue development. The project aims to (1) define the transcriptional and cellular disruptions to developing human neural cells caused by HCMV infection, (2) determine...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research aimed at advancing the understanding of T cell development and function. The $238,810 award to Cornell University will fund a 2-year project (9/1/2025 - 8/31/2027) to characterize the T cells produced by various embryonic progenitors and examine how the developmental origins of CD8+ T cells impact their immune function and response...
- This Project Grant award for $1,063,324 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on CD4+ T cell immunity in the respiratory tract, with a focus on understanding the mechanisms underlying host defense against extracellular pathogens, particularly in the area of Type 17 cytokines and tissue resident memory CD4+ T cells. The research will utilize murine and primate respiratory tract samples to assess the metabolic...
- This $525,095 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify novel cellular determinants of human cytomegalovirus (HCMV) infection. The University of Rochester, the primary awardee, aims to: Elucidate the mechanisms through which the cellular factor JUNB can restrict HCMV infection. JUNB is a stress-induced transcription factor that regulates...
The University of Toledo received a $162,000 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research) to conduct research on the cardioprotective role of fetal-derived CD8+ T cells during viral-induced myocarditis. The 2-year project aims to establish how T cells developed early in life regulate long-term cardiovascular disease consequences following cytomegalovirus (CMV) infection. The research will phenotypically and functionally characterize fetal versus adult-derived tissue-resident memory T cells, investigate their unique molecular signatures, and analyze their spatial distribution in the heart using advanced techniques such as single-cell RNA sequencing and spatial transcriptomics. This research seeks to provide fundamental knowledge on the immune response's role in regulating heart health during development, with implications for understanding and addressing cardiovascular complications associated with viral infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $162.0k | 7/28/25 |