Project Grant K08AI193194
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $807,330 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research focused on improving antibody-based protection against Plasmodium falciparum (P. falciparum) and Plasmodium vivax (P. vivax) malaria. The project aims to identify new antibody variants with at least...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for research on Pseudomonas aeruginosa infections and neutrophil swarming behavior. The funding will support a 2-year project to develop an ex vivo model to study how neutrophils coordinate to surround and neutralize large bacterial...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $197,640 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), on July 16, 2025. This grant supports research to investigate the contribution of a novel monocyte transcriptional state, termed Monocyte Substate 1 (MS1), to sepsis immunopathogenesis and patient heterogeneity. The project will...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $394,320 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to research how extracellular matrix (ECM) stiffness regulates the NLRP3 inflammasome in macrophages. The objective is to define the mechanisms by which ECM stiffness controls the NLRP3 inflammasome, which is relevant to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $406,450 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Harvard T.H. Chan School of Public Health. The grant supports research to develop a continuous in vitro culture system for the Plasmodium vivax malaria parasite. Key objectives include optimizing the production of host reticulocytes (young red blood cells) to support P. vivax growth, iteratively improving culture conditions...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant, titled "Role of ZNF Proteins in the Establishment and Maintenance of HIV Latency", will support research to evaluate the role of zinc finger (ZNF) proteins in establishing and maintaining HIV-1 reservoirs through...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $197,240 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the mechanisms by which fungal extracellular vesicles activate the innate immune system's interferon signaling pathways. The research aims to elucidate the role of the STING pathway in...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $800,005 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the structural basis and functional impacts of genetic variants in G-protein coupled receptors (GPCRs) associated with autoimmune diseases. The project aims to: 1) define the structural basis for impaired...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), awarded a $132,404 Project Grant to Yale University to determine the mechanism of cell death of small molecules produced by Pseudomonas aeruginosa against Acanthamoeba castellanii. Acanthamoeba castellanii is a free-living amoeba that causes fatal central nervous system infections, and this research aims to harness the amoebicidal compounds...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $179,140 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to establish the protozoan parasite Acanthamoeba as a modern model for studying infectious disease biology, comparative metabolism, and mitochondrial molecular biology. The 5-year research and career development plan, led by Dr. Jonathan Stefely, a postdoctoral researcher at MGH under the mentorship of Dr. Vamsi Mootha, aims to comprehensively characterize the unique mitochondrial biochemistry of Acanthamoeba that is not conserved in humans, with the goal of unlocking new biological insights and potential drug targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $179.1k | 8/8/25 |