Tuberculosis in malawian children under five years old: exploring non-invasive diagnostic strategies and the impact of malnutrition on treatment pharmacokinetics
Active Project Grant Awarded Last action
- Award ID
- K01TW012922
- Recipient
-
Michigan State University UEI NH77YPDEGG84
- Awarding agency
-
Fogarty International Center
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,112,688
Award facts
- Assistance listing
- 93.989 International Research and Research Training
- Completion date 43% complete
- Place of performance
- East Lansing, MI 48824, USA
Award details come from USAspending.gov.
Description
- Abstract
- The international research scientist development award will provide tremendous support for the candidate's transition to independence. The candidate is a pediatrician and rising pediatric infectious diseases physician with expertise caring for children with tuberculosis (TB) and severe acute malnutrition (SAM). The candidate's long-term goal is to conduct high-impact clinical studies and implementation research to improve detection and treatment of TB and other infectious diseases in children living in low-income countries. This award will provide the candidate with five years of mentored research and career development time, and he will spend >50% of the award period based at kamuzu university of health sciences (kuhes) and kuhes affiliate malawi liverpool wellcome clinical research program in blantyre, malawi. The candidate's primary mentors for this award are DR. Henry mwandumba (primary lmic-based mentor) and DR. Karl seydel (primary US mentor). DR. Mwandumba will provide excellent mentorship in the area of his expertise, implementing TB clinical studies in this setting. DR. Seydel brings a wealth of experience conducting high-impact pediatric clinical studies in blantyre and will provide guidance in this area. Through a combination of mentorship, coursework, and practical experiences, the candidate proposes to develop expertise in the following key areas: leadership and implementation of pediatric clinical research in malawi; advanced study design (including clinical trials) and statistical methods; and 3) pharmacokinetic study design and analysis. This training plan will coincide with, and complement, a rigorous research plan. The proposed research focuses on TB in children under five years old (U5S), an age group with unacceptably and disproportionately high mortality from TB. The large "case finding GAP" in this age group is a major problem globally and largely a consequence of the lack of TB diagnostic tools that are both practical and accurate in U5S. There is also a knowledge GAP regarding the effect of CO-prevalent SAM on the pharmacokinetics of first-line antituberculosis therapy in U5S. For aim 1 of the proposal, we plan conduct a prospective cohort study to evaluate the accuracy of promising new TB diagnostic strategies that utilize non-invasively collected specimens (stool and urine) in hospitalized malawian U5S with presumed pulmonary TB. For aim 2 of the proposal, we plan to longitudinally characterize the pharmacokinetics of first- line antituberculosis therapy (rifampin, isoniazid, pyrazinamide, and ethambutol) in malawian U5S with CO- prevalent SAM and TB as they recover from both diseases. This research will provide valuable insights into the diagnosis and management of TB in U5S and put the candidate in excellent position to secure independent research funding for more in-depth investigations in this setting in the areas of diagnostics and pharmacokinetics for pediatric TB and other infectious diseases that plague underserved children.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $184,441 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $184,453 | |
| Amendment | $184,453 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $186,447 | |
| Amendment | $186,447 | |
| Amendment | $186,447 | |
| Amendment | -$186,447 | |
| Amendment | -$186,447 | |
| Amendment | -$186,447 | |
| Amendment | $186,447 | |
| Amendment | $186,447 | |
| Original award | $186,447 |
Show all 17
Subawards
| Subrecipient | Amount | Awarded |
|---|---|---|
| Kamuzu University Of Health Sciences | $60,480 |
Quick answers
Who received award K01TW012922?
K01TW012922 was awarded to Michigan State University by Fogarty International Center (National Institutes of Health) on September 20, 2024.
How much is award K01TW012922 worth?
$1,112,688 has been obligated on K01TW012922.
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