Project Grant K01DK142001
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- This federal Project Grant award of $194,966 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a research project led by Dr. Joshua Cook at Columbia University's Health Sciences Division to investigate the pathophysiology of selective insulin resistance in humans. Specifically, the project aims to demonstrate that high insulin levels continue...
- This federal Project Grant award of $803,748 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant is funding research to investigate the modulation of insulin signaling in adipocytes (fat cells) and how improved adipocyte insulin sensitivity can contribute to positive metabolic outcomes. The research team at The University of Texas Southwestern Medical...
- This Project Grant award of $172,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of insulin receptor (IR) condensates in the development of insulin resistance and associated diseases, such as type 2 diabetes, obesity, and metabolic dysfunction-associated fatty liver disease. The research aims to 1)...
- This $168,252 federal Project Grant awarded on September 15, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Trustees of Boston University (DBA Boston University Medical Campus) to study the molecular mechanisms of nuclear receptor corepressors NCOR1 and SMRT and their role in regulating metabolism via actions in the intestine. The overarching goal is to expand...
- This federal Project Grant award of $672,737 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the role of mitochondria in dysregulated insulin secretion in obesity, which can lead to the development of type 2 diabetes. Specifically, the research aims to characterize the molecular determinants of fatty acid-induced...
- This $804,342 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at Duke University to investigate the metabolic actions of glucagon, a hormone that plays a key role in glucose regulation. Specifically, the research aims to characterize how glucagon receptor signaling in the liver engages divergent pathways that...
- This federal Project Grant award of $813,511 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research at the Dana-Farber Cancer Institute, Inc. (DFCI) to investigate the structural basis and functional consequences of thermogenic mitochondrial respiratory complexes assembly in the context of obesity and type 2 diabetes. The research aims to...
- The federal Project Grant award of $2,107,630 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support a longitudinal study to assess insulin vesicle functional capacity, beta cell mass, and pancreas volume in individuals at risk for and with recent onset type 1 diabetes. The study aims to utilize PET and MRI techniques to provide a comprehensive picture of beta...
- This federal Project Grant award of $802,843, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research conducted by Yale University to investigate the relationship between intestinal microbial activity and human metabolism. The key objectives are to: 1) understand how insulin resistance affects the adipose tissue lipolysis response to intestinal...
This $150,583 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to identify the primary drivers of altered insulin signaling and impaired glucose uptake ability in insulin resistance. Key objectives include: Identifying the upstream regulators and kinases driving the altered phosphorylation patterns observed in insulin resistance through phosphoproteome-based kinome analysis. Conducting a genome-wide CRISPR screen to identify the drivers of defective glucose uptake in insulin-resistant cells. The awardee, Joslin Diabetes Center, Inc., is a non-profit research organization in Boston, Massachusetts that specializes in advancing scientific understanding of diabetes and related metabolic conditions through fundamental research, clinical studies, and collaborative investigations. The award period is from September 15, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $150.6k | 9/12/25 |