Project Grant FA95502010386

This federal Project Grant award of $361,975.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will support the development of chemical probes to visualize and manipulate astrocytes, the brain's support cells, and their interactions with neurons. The funded research aims to expand on the awardee's preliminary work in designing chemical tags that can...

The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...

This federal Project Grant award of $446,126 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a new bioassay to study astrocyte borders and profile their functional states in the context of diverse non-neural cell populations. The key objectives are to optimize the bioassay by combining injectable cellulose-based hydrogels with viral vectors to...

This Project Grant award of $348,373 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), aims to develop a novel family of biosensors that can be used to report on and dynamically regulate changes in neuroinflammation within the brains of live animals. The key products and services to be delivered through this grant include: 1) Developing and...

The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (CFDA #93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the University of California, Davis to develop a miniature two-photon microscope that can simultaneously perform high-resolution calcium imaging and optogenetic manipulation of neural activity in freely-behaving mice. The project will integrate innovative beam forming techniques into a...

This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $2,260,440 to The Leland Stanford Junior University to investigate the cellular and molecular mechanisms regulating reactive astrocytes in glaucoma and other optic neuropathies. The key objectives are to: 1) establish the role of compartmentalized cAMP signaling and expression of the cell cycle inhibitor p21 in modulating astrocyte reactivity, microglial/macrophage...

The U.S. National Institutes of Health (NIH) awarded a $1,671,116 Cooperative Agreement grant under the Trans-NIH Research Support (CFDA 93.310) program to The Washington University in St. Louis. The 3-year grant, running from September 2023 to August 2026, aims to develop a novel two-component optogenetic system for reversibly controlling the activity of user-defined synaptic connections between specific cell types in the brain. The project will involve engineering light-sensitive G...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $556,525 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program to the Regents of the University of Michigan. The purpose of this 5-year project is to develop and validate high-density micro-LED optoelectrode platforms for artifact-free multi-color neuromodulation and neural circuit analysis in behaving animal models. The project aims to integrate...

This Project Grant award from the National Institutes of Health (NIH) Office of the Director under CFDA 93.310 - Trans-NIH Research Support program totals $1,490,348 and is aimed at testing an integrative hypothesis about the role of astrocytes in the brain's neuromodulator signaling systems. The award, made to the Research Foundation For Mental Hygiene, Inc. (RFMH) doing business as the New York Psychiatric Center, will utilize state-of-the-art cellular imaging and spatial transcriptomics...

This Project Grant award of $259,095 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), aims to develop an advanced optical imaging system capable of capturing the full electrical dynamics of thousands of neurons in the cortex and hippocampus of awake, behaving rodents. The project will leverage a combination of structured one-photon excitation and light field detection to achieve high-speed volumetric imaging of genetically encoded voltage...