Project Grant F32NS148600
- The National Institute of Neurological Disorders and Stroke awarded The Scripps Research Institute $710,155 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate post-transcriptional mechanisms of cortical inhibitory interneuron development. The research focuses on identifying how microRNA-mediated regulation controls interneuron migration and specification during development. The work employs engineered...
- The National Institute of Neurological Disorders and Stroke awarded President and Fellows of Harvard College $151,352 on August 27, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate developmental activity and function of layer 5 cortical circuits following early postnatal reorganization. The research examines how inhibitory somatostatin-expressing cortical interneurons develop targeting specificity for distinct...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded Massachusetts Institute of Technology $436,242 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support predoctoral training in neuroscience and cognitive science. MIT's Department of Brain and Cognitive Sciences will deliver interdisciplinary graduate training spanning cellular and...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services, awarded $429,000 to The Regents of the University of Colorado, doing business as University of Colorado-Denver, on September 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Program Grant R21NS151067). The award funds research on transcriptional and epigenetic regulation of neural progenitor fates during...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded $120,582 to President and Fellows of Harvard College (operating as Harvard Medical School) on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining the functional specializations of cerebellar interneuron subtypes and their roles...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
- The National Institute of Neurological Disorders and Stroke awarded The Broad Institute, Inc. $404,282 on May 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to engineer transferrin receptor 1 (TFR1) binding adeno-associated virus (AAV) capsids that evade pre-existing neutralizing antibodies while maintaining central nervous system delivery capability. The funded research addresses a critical barrier to AAV gene therapy for...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $100,228 on December 16, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research on complement-mediated mechanisms of injury and repair in germinal matrix hemorrhage, a leading neurological injury of prematurity....
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $120,582 to President and Fellows of Harvard College on January 17, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating motor learning mechanisms in cortico-basal ganglia circuits. The project explores how neural circuits generate behavioral...
- The National Institute of Neurological Disorders and Stroke awarded $104,288 to President and Fellows of Harvard College on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). Harvard's Office for Sponsored Programs will develop a high-throughput molecular connectomics tool with synaptic resolution to map the molecular basis of synapse formation and specification. The work integrates neuronal wiring diagrams with...
The National Institute of Neurological Disorders and Stroke (NINDS), part of the Department of Health and Human Services National Institutes of Health, awarded $153,560 to the Broad Institute, Inc. (doing business as Broad Institute of MIT and Harvard) on December 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research examining how excitatory neurons regulate interneuron fate, position, and survival during cortical development. The work tests the hypothesis that distinct excitatory neuron populations influence interneuron development at discrete developmental stages using cre-conditional knockout approaches, single-nucleus RNA-seq, and spatial transcriptomics. In Aim 1, the research knocks out TBR1 or SATB2 transcription factors in early-born transient excitatory populations—Cajal-Retzius and subplate neurons—to assess their role in regulating interneuron fate and positioning during migration. In Aim 2, the work knocks out TBR1 or SATB2 in layer-specific pyramidal neurons to test how changes in pyramidal neuron identity affect interneuron subtype fate and position, with investigation of whether changes in subtype proportions relate to changes in cell survival. The research addresses how disruptions in excitatory-inhibitory balance contribute to neurodevelopmental disorders such as autism spectrum disorder. Period of performance runs from December 1, 2026, through January 31, 2029. Work is performed in Cambridge, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $76.8k | 5/5/26 | ||
| Not listed | $0 | 5/5/26 | ||
| Not listed | $76.8k | 5/5/26 |