Project Grant F32MH143407
- The National Institute of Mental Health awarded the University of Puerto Rico Medical Sciences Campus $706,471 on August 5, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize the neuronal substrates governing approach and avoidance conflict behavior in mice. The recipient will conduct three research aims using fiber photometry, virally-mediated cellular signal ablation, and optogenetics in mice trained in platform-mediated avoidance tasks. Aim 1 characterizes how...
- This $409,750 project grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) aims to characterize the role of ventral pallidal astrocytes in approach/avoidance conflict behaviors in mice. The 2-year project, running from April 1, 2025 to March 31, 2027, will utilize fiber photometry and chemogenetic manipulations to investigate how astrocytes in the ventral pallidum regulate synapses and influence approach/avoidance behaviors...
- The National Institute of Mental Health awarded Massachusetts Eye and Ear Infirmary $666,010 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to study co-transmission of GABA and glutamate in cortical circuits and the role of neuromodulatory inputs in adult cortical plasticity. The recipient will employ anatomical circuit tracing, whole-cell electrophysiology, and in vivo two-photon imaging in mouse cortex to investigate how cholinergic and serotonergic...
- The National Institute of Mental Health awarded the University of Miami $731,258 on March 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to map neural dynamics linked to major depressive disorder and generalized anxiety disorder using high-stakes real-world events. The recipient will conduct fMRI neuroimaging across five sessions with 144 undergraduate participants—72 diagnosed with GAD or MDD and 72 controls—leveraging naturally occurring emotional events during...
- The National Institute of Mental Health awarded The Regents of the University of California, San Francisco $800,384 on March 10, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct molecular and functional dissection of prefrontal-hippocampal long-range inhibition. The project investigates a novel long-range GABAergic pathway from prefrontal cortex to hippocampus that mediates top-down control of hippocampal function. The research will elucidate mechanisms through...
- The National Institute of Mental Health awarded the University of Pittsburgh $158,960 on January 21, 2027, under the Mental Health Research Grants program (CFDA 93.242) to investigate inhibitory control of dendritic spikes in hippocampal CA1 pyramidal neurons. The project will use optogenetics, two-photon calcium imaging, and voltage imaging to explore how dendrite-targeting somatostatin interneurons regulate dendritic spike dynamics, specifically examining how synaptic inhibition modifies...
- The National Institute of Mental Health awarded the University of California, Los Angeles $180,670 on October 25, 2025, under the Mental Health Research Grants program (CFDA 93.242) to conduct research on the neuronal correlates of avoidance and pursuit during human ambulatory navigation. The project investigates how the medial temporal lobe, including the hippocampus and amygdala, supports simultaneous reward-seeking and risk-aversion during naturalistic navigation in freely-moving humans. UCLA...
- The National Institute of Mental Health awarded the University of California, San Diego $164,190 on December 30, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate the neural circuit mechanism by which hunger suppresses socio-affective behavior in mice. The research addresses a gap in understanding how the brain prioritizes feeding over social behaviors during hunger and applies findings to neuropsychiatric conditions—including anxiety, depression, and autism...
- The National Institute of Mental Health awarded Trustees of Boston University $449,625 on July 9, 2026, under the Mental Health Research Grants program (CFDA 93.242) to conduct basic neuroscience research on behavioral functions of cotransmission in cost/benefit decision-making. The research examines how dopamine release in distinct striatal subregions supports different forms of learning—reward-based versus threat-based—and tests a specialized neural circuit linking the tail of the striatum,...
- The National Institute of Mental Health awarded Oregon Health & Science University $301,936 on December 30, 2025, under the Mental Health Research Grants program (CFDA 93.242) to investigate how dendritic protein kinase activity in external globus pallidus neurons relates to spontaneous firing activity and controls integration of inhibitory striatal synaptic inputs in the basal ganglia. The research addresses dysfunctions of basal ganglia circuitry thought to underlie obsessive-compulsive...
The National Institute of Mental Health awarded $158,696 to the University of Puerto Rico Medical Sciences Campus on December 2, 2026, under the Mental Health Research Grants program (CFDA 93.242) to investigate how GABAergic neurons in the ventral pallidum and their projections to the lateral hypothalamus encode and modulate opposing behavioral responses during motivational conflict. The research uses fiber photometry and optogenetics to characterize how ventral pallidum GABAergic neuronal activity encodes reward- and threat-related cues during the platform-mediated avoidance task, a behavioral paradigm in which mice learn to approach a sucrose reward signaled by light and avoid mild footshock signaled by tone. The study employs closed-loop silencing of ventral pallidum GABAergic neurons during key behavioral epochs to determine whether temporally precise intervention impairs approach or avoidance responses, with the goal of clarifying how these motivational circuits contribute to adaptive decision-making processes often disrupted in anxiety, depression, and addiction-related disorders. The award is a Project Grant with a period of performance extending from December 2, 2026, through June 4, 2029. Performance takes place in Puerto Rico, with the University of Puerto Rico Medical Sciences Campus serving as the recipient organization under its parent institution, the University of Puerto Rico.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $79.3k | 6/5/26 | ||
| Not listed | $79.3k | 6/5/26 | ||
| Not listed | $0 | 6/5/26 |