Project Grant F32GM167172
- The National Cancer Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded Beth Israel Deaconess Medical Center, Inc. $524,110 on June 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393, Assistance Listing Project Grant R01CA314254). The award funds research on one-ended break repair mechanisms in mammalian cells, specifically investigating how cells repair DNA damage at broken replication forks and double-strand...
- The National Institute of General Medical Sciences awarded the University of Massachusetts Medical School $1.34 million on September 15, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms of histone octamer transfer activity in BAF chromatin remodeling complexes and their relationship to cancer formation and neurodevelopmental disorders. The research examines the ARID1A subunit of CBAF complexes, which is mutated in over 20...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Brigham & Women's Hospital Inc. $230,388 on March 12, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop small molecule inhibitors of the E3 ligase NEDD4. The project consists of two research aims. Aim 1 investigates the structural dynamics of the NEDD4 HECT domain through NMR spectroscopy, using different...
- The National Institute of General Medical Sciences, a component of the Department of Health and Human Services, awarded $440,465 to the Massachusetts Institute of Technology on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop biophysical models of genome folding and function. Over the five-year performance period ending February 28, 2031, the award funds research into chromosome architecture and the mechanisms that shape it—motor-driven loop...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $300,196 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct structural investigations into the regulatory states of human ribonucleotide reductase using cryogenic electron microscopy. The project uses cryo-EM to determine structures of the human RNR protein in both active and inactive states. The first aim involves determining cryo-EM structures...
- The National Institute of General Medical Sciences awarded the Trustees of Boston University $433,750 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop network-based computational models for understanding continuous cell states in human development and disease. Over five years through February 28, 2031, the research group will create methods to integrate multiple modalities of large-scale genomics data, with emphasis on epigenetics and the...
- The National Institute of General Medical Sciences awarded The Broad Institute, Inc. $464,032 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop computational methods for mapping intercellular circuits governing complex tissues, specifically mucosal epithelia in the intestine, airway, nose, urogenital tract, and related barrier surfaces. The project addresses two key analytical challenges: uncovering intercellular regulatory signals that...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $127,567 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of nuclease-based bacterial immunity systems. The research, carried out in Cambridge, Massachusetts, through August 31, 2028, combines genetic and molecular biology approaches with training in biochemistry, structural biology, and computational methods to dissect how...
- The National Institute of General Medical Sciences awarded $498,000 to Trustees of Tufts College on September 15, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support research elucidating the epigenetic regulation of extracellular matrix and virus-induced fibroblast activation. The project investigates how epigenetic mechanisms control the sustained activation of fibroblasts into myofibroblasts during fibrotic disease, focusing on the role of BRG1...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Massachusetts General Hospital $761,577 on March 15, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of histone methylation marks in blood cell development. The research interrogates how H3K4 and H3K27 histone methylation regulate hematopoiesis using novel histone mutant transgenic tools. Preliminary work demonstrated that H3K4 methylation is...
The National Institute of General Medical Sciences awarded Beth Israel Deconess Medical Center, Inc. $158,600 on January 23, 2027, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct single-molecule dissection of hypomethylation-driven genome instability. The research combines technology development with mechanistic chromatin biology to address how global DNA hypomethylation—an early epigenetic alteration in human cancer—drives chromosomal instability and DNA breaks. Aim 1 develops an Oxford Nanopore Technologies-based single-molecule platform to jointly map endogenous DNA breaks and DNA methylation, overcoming limitations of existing break-mapping assays. Aim 2 uses the new method alongside INDUCE-SEQ and whole-genome bisulfite sequencing to define how DNMT1-inhibitor-induced DNA breaks relate to local methylation loss in USP48-deficient leukemia cells. Aim 3 dissects how the histone deubiquitinase USP48 regulates MACROH2A1 ubiquitination to promote DNA repair under hypomethylating stress, using CRISPR-engineered mutants, quantitative imaging, and DNA damage-response assays. The research identifies USP48 and MACROH2A1 as key regulators of genome integrity and establishes a mechanistic framework for how hypomethylation drives genome fragility, informing safer and more effective use of hypomethylating agents approved for leukemia and under investigation across other cancer types. Performance occurs in Massachusetts. The period of performance runs from January 23, 2027, through August 23, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/23/26 | ||
| Not listed | $79.3k | 7/23/26 |