Application of the spread method to xfel serial crystallography for the spatial and temporal resolution of metalloenzyme electronic structures
Active Project Grant Awarded Last action
- Award ID
- F32GM161078
- Recipient
-
The Regents Of The University Of California UEI ENBLDJUN4N73
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $76,300
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 0% complete
- Place of performance
- Berkeley, CA 94720, USA
Award details come from USAspending.gov.
Description
- Abstract
- Metalloenzymes are crucial in mediating biological processes. Catalysis is controlled by precise movement of protons and electrons at active sites, which are often coordinated with ligand binding, side-chain movement, or larger protein conformational changes. To fully characterize enzyme mechanisms, simultaneous interrogation of protein structure and the metal oxidation state of each atom in their metallocofactors is required. A key motivation of this proposal is to understand the mechanism of photosystem II (PSII), where the coordinated movement of substrate and electrons within a MN4CAO5 cofactor catalyzes biological water oxidation. These research questions can be addressed by X-RAY crystallography by analyzing the anomalous scattering of each metal atom, even for metallocofactors which contain multiple copies of the same element. The spatially resolved anomalous dispersion (SPREAD) method depends on the wavelength dependent behavior of scatterers around their absorption K-edge. With a tunable and monochromatic X-RAY source with a resolution of
Quick answers
Who received award F32GM161078?
F32GM161078 was awarded to The Regents Of The University Of California by National Institute of General Medical Sciences (National Institutes of Health) on February 15, 2027.
How much is award F32GM161078 worth?
$76,300 has been obligated on F32GM161078.
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