Project Grant F32DK149604
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Trustees of Columbia University in the City of New York $123,375 on August 20, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct structure-guided research aimed at preventing polymyxin-induced acute kidney injury. The project will characterize the interaction between polymyxin B and the endocytic receptor LRP2/megalin using cross-linking mass spectrometry...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $691,758 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate DCLK1 isoform switching and its role in proximal tubule injury during kidney disease progression. The award funds basic research to understand how DCLK1 regulates inflammation and DNA damage response pathways in injured proximal tubule cells, which...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $388,750 on April 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the structural and functional mechanisms of podocin in glomerular membrane organization and kidney disease. The research applies detergent-free, vesicle-based cryo-electron microscopy to determine the full-length structure of podocin at near-atomic resolution...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Purdue University $120,937 on July 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop bioinspired, multi-antioxidant nanomedicine for treating acute kidney injury. The award funds synthesis and evaluation of a library of sub-5 nanometer chalcogen-phenolic nanoparticles (CPNP) designed to neutralize reactive oxygen species in kidney tissue while accumulating...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Trustees of Columbia University in the City of New York $859,998 as a Project Grant on January 23, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research into kidney disease mechanisms in individuals with DiGeorge syndrome, a microdeletion disorder affecting one in 2,000–4,000 live births. The research combines genetics, transcriptomics, and...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the Veterans Medical Research Foundation of San Diego $383,098 on September 2, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The recipient will conduct research into kidney tubule dysfunction in APOL1-associated chronic kidney disease, with focus on developing and validating tubular biomarkers that capture kidney functions—nutrient reabsorption and toxin...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded the University of Pennsylvania $258,031 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to employ long-read RNA sequencing to comprehensively characterize alternative splicing events in kidney tissue and their role in chronic kidney disease. The recipient will conduct bulk kidney tissue analysis to identify novel isoforms and compare isoform expression between...
- The National Institute of Diabetes and Digestive and Kidney Diseases, an institute within the Department of Health and Human Services National Institutes of Health, awarded the Regents of the University of Michigan $690,854 on February 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to identify molecular and genetic mechanisms that determine and maintain kidney epithelial cell states in normal physiology and in...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Duke University $1,636,543 on March 17, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of the ubiquitin editor A20 in regulating sodium transport and the hypertensive response through selective actions in kidney epithelial cells and tubules. The research addresses the mechanisms through which A20 suppresses inflammatory cytokines that modulate...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Washington University $766,951 on April 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop and validate imaging biomarkers for assessing high-risk deceased donor kidneys slated for transplantation. The project addresses kidney shortage by improving the accuracy of kidney quality assessment, reducing the approximately 2,500 procured kidneys discarded...
The National Institute of Diabetes and Digestive and Kidney Diseases awarded The Trustees of Princeton University $151,760 on January 9, 2027, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to develop kidney-targeted drug delivery using solute carrier transporters. The research establishes proof-of-concept for exploiting cystine transporters SLC7A9 and SLC7A13, which are highly expressed in kidney tissue, to deliver drugs selectively to kidney cells. The recipient's laboratory has developed cystine transporter-aimed motifs (CTAMs)—inert cystine analogs that serve as substrates for these transporters. Drugs conjugated to CTAMs can be transported into kidney cells and released via cleavable linkers, a strategy termed SLC hijacking. Aim 1 identifies CTAM-drug conjugates that exploit these transporters for kidney-specific delivery by assessing uptake and activity in cell culture systems, conducting in vivo studies using wild-type and transporter knockout mice, and using MALDI-MS imaging to map intra-kidney localization. Aim 2 evaluates the therapeutic potential of CTAM-prednisolone conjugates in a chronic kidney disease mouse model, assessing efficacy in reducing renal inflammation and determining whether kidney-specific delivery mitigates systemic toxicity and adrenal insufficiency. Work is performed in Princeton, New Jersey. The period of performance runs from January 9, 2027, through July 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 7/17/26 | ||
| Not listed | $75.9k | 7/17/26 | ||
| Not listed | $75.9k | 7/17/26 |