Differential modulation of spinal sensory and motor circuits through spatially constrained serotonin release
Active Project Grant Awarded Last action
- Award ID
- F31NS151912
- Recipient
-
University Of Utah UEI LL8GLEVH6MG3
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $40,228
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 0% complete
- Place of performance
- Salt Lake City, UT 84112, USA
Award details come from USAspending.gov.
Description
- Abstract
- Serotonin is a neuromodulator whose roles in neuropsychiatric conditions like anxiety and depression are well known. However, the roles that serotonin plays in regulating behavior through the modulation of spinal sensory and motor control are less understood. I showed that two hindbrain serotonergic neuron populations, the dorsal raphe nucleus and the caudal raphe nucleus, differentially project to the sensory and motor regions of the spinal cord in larval zebrafish. Whether and how the anatomy of these projections influences spinal serotonin release during naturalistic behavior, and whether such release allows sensory and motor process to be modulated independently, has not been studied. In the experiments i outline in this proposal, i will characterize the activity of serotonergic raphe neurons during a variety of sensorimotor behaviors (aim 1) and determine whether this activity leads to spatially precise patterns of serotonin release in the spinal cord (aim 2). I will additionally determine whether distinct raphe nuclei populations are necessary and sufficient to facilitate different aspects of sensory and motor behaviors through transient optogenetic manipulations (aim 3). These experiments will reveal the functional organization of the neural circuitry by which a single modulatory molecule intricately controls animal behavior in an ever-changing sensory environment.
Quick answers
Who received award F31NS151912?
F31NS151912 was awarded to University Of Utah by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on February 15, 2027.
How much is award F31NS151912 worth?
$40,228 has been obligated on F31NS151912.
On GovTribe
See this award's full record
- Every transaction and subaward
- The recipient's other awards and teaming partners
- Similar grant awards
- Ask GovTribe AI about this award