Regeneration of thalamopallial projections and sensory function in the salamander brain
Active Project Grant Awarded Last action
- Award ID
- F31NS141628
- Recipient
-
The Trustees Of Columbia University In The City Of New York UEI F4N1QNPB95M4
- Awarding agency
-
National Institute of Neurological Disorders and Stroke
National Institutes of Health, Department of Health and Human Services
- Obligated
- $297,240
Award facts
- Assistance listing
- 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders
- Completion date 62% complete
- Place of performance
- New York, NY 10027, USA
Award details come from USAspending.gov.
Description
- Abstract
- The pallium is a significant vertebrate brain division that includes the mammalian cerebral cortex. In salamanders, the pallium exhibits a remarkable ability to regenerate neurons, making this a valuable model to understand how function can be restored in injured brains. Although pallial neurons can regenerate, we do not know if synaptic inputs to the regenerated pallium are restored. The project uses whole brain light sheet microscopy to examine whether inputs to the pallium from the thalamus are restored after a large pallial lesion. The first aim in this proposal will map and compare thalamopallial projections in the uninjured and regenerated pallium. These experiments will demonstrate whether the regenerated pallium is RE-innervated by thalamic axons following pallial lesion. The second aim describe the regionalized activity of pallial neurons in response to thalamic sensory stimuli. These experiments will determine whether regionalized sensory activity returns in the regenerated pallial area. This research project will support the fellow's development of skills that include image analysis, neuron tracing, and scientific communication.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $576 | |
| Amendment | $49,538 | |
| Amendment | $49,538 | |
| Amendment | $564 | |
| Amendment | $564 | |
| Amendment | $564 | |
| Amendment | $48,974 | |
| Amendment | $48,974 | |
| Amendment | $0 | |
| Amendment | $48,974 | |
| Amendment | $0 | |
| Amendment | $0 | |
| Original award | $48,974 |
Show all 13
Quick answers
Who received award F31NS141628?
F31NS141628 was awarded to The Trustees Of Columbia University In The City Of New York by National Institute of Neurological Disorders and Stroke (National Institutes of Health) on May 1, 2025.
How much is award F31NS141628 worth?
$297,240 has been obligated on F31NS141628.
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